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The salicylic acid dependent and independent effects of NMD in plants

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Rayson, Samantha, Ashworth, Mary, Torres Zabala, Marta de, Grant, Murray and Davies, Brendan (2012) The salicylic acid dependent and independent effects of NMD in plants. Plant Signaling & Behavior, 7 (11). pp. 1434-1437. doi:10.4161/psb.21960 ISSN 1559-2316.

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Official URL: http://dx.doi.org/10.4161/psb.21960

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Abstract

In eukaryotes, nonsense-mediated mRNA decay (NMD) targets aberrant and selected non-aberrant mRNAs for destruction. A recent screen for mRNAs showing increased abundance in Arabidopsis NMD-deficient mutants revealed that most are associated with the salicylic acid (SA)-mediated defense pathway. mRNAs with conserved peptide upstream open reading frames (CpuORFs or CuORFs) are hugely overrepresented among the smaller class of NMD-regulated transcripts not associated with SA. Here we show that the common phenotypes observed in Arabidopsis NMD mutants are SA-dependent, whereas the upregulation of CpuORF-containing transcripts in NMD mutants is independent of SA. We speculate that CpuORFs could allow the conditional targeting of mRNAs for destruction using the NMD pathway.

Item Type: Journal Article
Subjects: S Agriculture > SB Plant culture
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Salicylic acid, Arabidopsis, Messenger RNA
Journal or Publication Title: Plant Signaling & Behavior
Publisher: Landes Bioscience
ISSN: 1559-2316
Official Date: 2012
Dates:
DateEvent
2012Published
Volume: 7
Number: 11
Number of Pages: 4
Page Range: pp. 1434-1437
DOI: 10.4161/psb.21960
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 8 April 2016
Date of first compliant Open Access: 8 April 2016
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BB/H00775X/1 (BBSRC)

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