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The salicylic acid dependent and independent effects of NMD in plants
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Rayson, Samantha, Ashworth, Mary, Torres Zabala, Marta de, Grant, Murray and Davies, Brendan (2012) The salicylic acid dependent and independent effects of NMD in plants. Plant Signaling & Behavior, 7 (11). pp. 1434-1437. doi:10.4161/psb.21960 ISSN 1559-2316.
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Official URL: http://dx.doi.org/10.4161/psb.21960
Abstract
In eukaryotes, nonsense-mediated mRNA decay (NMD) targets aberrant and selected non-aberrant mRNAs for destruction. A recent screen for mRNAs showing increased abundance in Arabidopsis NMD-deficient mutants revealed that most are associated with the salicylic acid (SA)-mediated defense pathway. mRNAs with conserved peptide upstream open reading frames (CpuORFs or CuORFs) are hugely overrepresented among the smaller class of NMD-regulated transcripts not associated with SA. Here we show that the common phenotypes observed in Arabidopsis NMD mutants are SA-dependent, whereas the upregulation of CpuORF-containing transcripts in NMD mutants is independent of SA. We speculate that CpuORFs could allow the conditional targeting of mRNAs for destruction using the NMD pathway.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | S Agriculture > SB Plant culture | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Library of Congress Subject Headings (LCSH): | Salicylic acid, Arabidopsis, Messenger RNA | ||||
| Journal or Publication Title: | Plant Signaling & Behavior | ||||
| Publisher: | Landes Bioscience | ||||
| ISSN: | 1559-2316 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | 7 | ||||
| Number: | 11 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 1434-1437 | ||||
| DOI: | 10.4161/psb.21960 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Date of first compliant deposit: | 8 April 2016 | ||||
| Date of first compliant Open Access: | 8 April 2016 | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | BB/H00775X/1 (BBSRC) |
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