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A role for nonsense-mediated mRNA decay in plants : pathogen responses are induced in Arabidopsis thaliana NMD mutants

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Newbigin, Edward, Rayson, Samantha, Arciga-Reyes, Luis, Wootton, Lucie, Torres Zabala, Marta de, Truman, William, Graham, Neil, Grant, Murray and Davies, Brendan (2012) A role for nonsense-mediated mRNA decay in plants : pathogen responses are induced in Arabidopsis thaliana NMD mutants. PLoS One, 7 (2). pp. 1-13. e31917. doi:10.1371/journal.pone.0031917 ISSN 1932-6203.

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Official URL: http://dx.doi.org/10.1371/journal.pone.0031917

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Abstract

Nonsense-mediated mRNA decay (NMD) is a conserved mechanism that targets aberrant mRNAs for destruction. NMD has also been found to regulate the expression of large numbers of genes in diverse organisms, although the biological role for this is unclear and few evolutionarily conserved targets have been identified. Expression analyses of three Arabidopsis thaliana lines deficient in NMD reveal that the vast majority of NMD-targeted transcripts are associated with response to pathogens. Congruently, NMD mutants, in which these transcripts are elevated, confer partial resistance to Pseudomonas syringae. These findings suggest a biological rationale for the regulation of gene expression by NMD in plants and suggest that manipulation of NMD could offer a new approach for crop protection. Amongst the few non-pathogen responsive NMD-targeted genes, one potential NMD targeted signal, the evolutionarily conserved upstream open reading frame (CuORF), was found to be hugely over-represented, raising the possibility that this feature could be used to target specific physiological mRNAs for control by NMD.

Item Type: Journal Article
Subjects: S Agriculture > SB Plant culture
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Arabidopsis thaliana, Messenger RNA
Journal or Publication Title: PLoS One
Publisher: Public Library of Science
ISSN: 1932-6203
Official Date: 2012
Dates:
DateEvent
2012UNSPECIFIED
Volume: 7
Number: 2
Number of Pages: 13
Page Range: pp. 1-13
Article Number: e31917
DOI: 10.1371/journal.pone.0031917
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 5 April 2016
Date of first compliant Open Access: 5 April 2016
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)

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