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An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development
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Holt, Ben F., Boyes, Douglas C., Ellerström, Mats, Siefers, Nicholas, Wiig, Aaron, Kauffman, Scott, Grant, Murray and Dangl, Jeffery L. (2002) An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development. Developmental Cell, 2 (6). pp. 807-817. doi:10.1016/S1534-5807(02)00233-2 ISSN 1534-5807.
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Official URL: http://dx.doi.org/10.1016/S1534-5807(02)00174-0
Abstract
Plants recognize many pathogens through the action of a diverse family of proteins called disease resistance (R) genes. The Arabidopsis R gene RPM1 encodes resistance to specific Pseudomonas syringae strains. We describe an RPM1-interacting protein that is an ortholog of TIP49a, previously shown to interact with the TATA binding protein (TBP) complex and to modulate c-myc- and β-catenin-mediated signaling in animals. Reduction of Arabidopsis TIP49a (AtTIP49a) mRNA levels results in measurable increases of two R-dependent responses without constitutively activating defense responses, suggesting that AtTIP49a can act as a negative regulator of at least some R functions. Further, AtTIP49a is essential for both sporophyte and female gametophyte viability. Thus, regulators of R function overlap with essential modulators of plant development.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Developmental Cell | ||||
Publisher: | Cell Press | ||||
ISSN: | 1534-5807 | ||||
Official Date: | 2002 | ||||
Dates: |
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Volume: | 2 | ||||
Number: | 6 | ||||
Page Range: | pp. 807-817 | ||||
DOI: | 10.1016/S1534-5807(02)00233-2 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Description: | In this article (Developmental Cell 2, 807–817, June, 2002), the title to the legend of Figure 4 contains an error. The correct title is given below: Figure 4. RPP2 Function Is Enhanced in Several tip49as Lines |
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