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Ricin: the endoplasmic reticulum connection
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UNSPECIFIED (2004) Ricin: the endoplasmic reticulum connection. TOXICON, 44 (5). pp. 469-472. ISSN 0041-0101
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Official URL: http://dx.doi.org/10.1016/j.toxicon.2004.07.002
Abstract
Ricin is a potent, plant-derived, ribosome inactivating protein. To target ribosomes in the mammalian cytosol, ricin must firstly negotiate the endomembrane system of the cell to reach the endoplasmic reticulum. Here, the toxin is reduced and the catalytic A chain is recognised by ER components that facilitate its membrane translocation to the cytosol. To be toxic, ricin A chain must then avoid degradation, a conundrum made more tricky in that ubiquitination and proteasomal degradation are normally tightly coupled to the translocation process. This mini-review summarieses current understanding of these events. (C) 2004 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Item |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RA Public aspects of medicine |
| Journal or Publication Title: | TOXICON |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0041-0101 |
| Date: | October 2004 |
| Volume: | 44 |
| Number: | 5 |
| Number of Pages: | 4 |
| Page Range: | pp. 469-472 |
| Identification Number: | 10.1016/j.toxicon.2004.07.002 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/7841 |
Data sourced from Thomson Reuters' Web of Knowledge
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