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Keeping a lid on nodal : transcriptional and translational repression of nodal signalling

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Sampath, Karuna and Robertson, Elizabeth J. (2016) Keeping a lid on nodal : transcriptional and translational repression of nodal signalling. Open Biology, 6 (1). 150200. doi:10.1098/rsob.150200

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Official URL: http://dx.doi.org/10.1098/rsob.150200

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Abstract

Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from hydra and sea urchins to fish, mice and humans. In addition to embryonic patterning, Nodal signalling is required for maintenance of human embryonic stem cell pluripotency and mis-regulated Nodal signalling has been found associated with tumour metastases. Therefore, precise and timely regulation of this pathway is essential. Here, we discuss recent evidence from sea urchins, frogs, fish, mice and humans that show a role for transcriptional and translational repression of Nodal signalling during early development.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Developmental biology, Cytology , Genetics
Journal or Publication Title: Open Biology
Publisher: The Royal Society Publishing
ISSN: 2046-2441
Official Date: 20 January 2016
Dates:
DateEvent
20 January 2016Published
14 December 2015Accepted
18 October 2015Submitted
Volume: 6
Number: 1
Number of Pages: 8
Article Number: 150200
DOI: 10.1098/rsob.150200
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Warwick Medical School

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