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Keeping a lid on nodal : transcriptional and translational repression of nodal signalling
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Sampath, Karuna and Robertson, Elizabeth J. (2016) Keeping a lid on nodal : transcriptional and translational repression of nodal signalling. Open Biology, 6 (1). 150200. doi:10.1098/rsob.150200
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Official URL: http://dx.doi.org/10.1098/rsob.150200
Abstract
Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from hydra and sea urchins to fish, mice and humans. In addition to embryonic patterning, Nodal signalling is required for maintenance of human embryonic stem cell pluripotency and mis-regulated Nodal signalling has been found associated with tumour metastases. Therefore, precise and timely regulation of this pathway is essential. Here, we discuss recent evidence from sea urchins, frogs, fish, mice and humans that show a role for transcriptional and translational repression of Nodal signalling during early development.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Developmental biology, Cytology , Genetics | ||||||||
| Journal or Publication Title: | Open Biology | ||||||||
| Publisher: | The Royal Society Publishing | ||||||||
| ISSN: | 2046-2441 | ||||||||
| Official Date: | 20 January 2016 | ||||||||
| Dates: |
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| Volume: | 6 | ||||||||
| Number: | 1 | ||||||||
| Number of Pages: | 8 | ||||||||
| Article Number: | 150200 | ||||||||
| DOI: | 10.1098/rsob.150200 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Warwick Medical School |
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