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Dosing-time makes the poison : circadian regulation and pharmacotherapy
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Dallmann, Robert, Okyar, Alper and Lévi, Francis A. (2016) Dosing-time makes the poison : circadian regulation and pharmacotherapy. Trends in Molecular Medicine, 22 (5). pp. 430-445. doi:10.1016/j.molmed.2016.03.004 ISSN 1471-4914.
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Official URL: http://dx.doi.org/10.1016/j.molmed.2016.03.004
Abstract
Daily rhythms in physiology significantly modulate drug pharmacokinetics and pharmacodynamics according to the time-of-day, a finding that has led to the concept of chronopharmacology. The importance of biological clocks for xenobiotic metabolism has gained increased attention with the discovery of the molecular circadian clockwork. Mechanistic understanding of the cell-autonomous molecular circadian oscillator and the circadian timing system as a whole has opened new conceptual and methodological lines of investigation to understand first, the clock's impact on a specific drug's daily variations or the effects/side effects of environmental substances, and second, how clock-controlled pathways are coordinated within a given tissue or organism. Today, there is an increased understanding of the circadian modulation of drug effects. Moreover, several molecular strategies are being developed to treat disease-dependent and drug-induced clock disruptions in humans.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Circadian rhythms, Drugs -- Metabolism | ||||||||
Journal or Publication Title: | Trends in Molecular Medicine | ||||||||
Publisher: | Elsevier Ltd. | ||||||||
ISSN: | 1471-4914 | ||||||||
Official Date: | May 2016 | ||||||||
Dates: |
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Volume: | 22 | ||||||||
Number: | 5 | ||||||||
Page Range: | pp. 430-445 | ||||||||
DOI: | 10.1016/j.molmed.2016.03.004 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 18 April 2016 | ||||||||
Date of first compliant Open Access: | 5 April 2017 | ||||||||
Funder: | Cancer Research UK (CRUK) |
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