The Library
Investigation of work of adhesion of biological cell (human hepatocellular carcinoma) by AFM nano-indentation
Tools
Zhu, Xinyao, Liu, Xianping, Zhang, Nana and Wang, Zuobin (2015) Investigation of work of adhesion of biological cell (human hepatocellular carcinoma) by AFM nano-indentation. In: 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), Changchun, 5-9 Oct 2015. Published in: 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) pp. 147-152. doi:10.1109/3M-NANO.2015.7425498
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1109/3M-NANO.2015.7425498
Abstract
In this study, we presented investigation of mechanical properties by AFM nanoindentation on human hepatocellular carcinoma cells treated with fullerenol for 24, 48 and 72 hours. Atomic force microscope was routinely used to investigate the morphology and biomechanical properties of living carcinoma cells, and adhesion phenomenon (negative force) was detected in the obtained force-displacement curves. Conventionally, Hertz contact model has been widely used for determination of cell elasticity, however this contact model cannot account for adhesion. Alternatively, JKR contact model, as expected for adhesion circumstance, was used to fit the obtained force-displacement curves, resulting a new parameter termed work of adhesion in addition to Young's modulus. The fitting results show that not only Young's modulus but also work of adhesion exhibit significant variation as the treatment period increases. The investigation suggests that work of adhesion may also serve as an effective bio-index to evaluate the effects of fullerenol or other anticancer agents on cancer cells, and provide insight into cancer progression.
Item Type: | Conference Item (Paper) | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Journal or Publication Title: | 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) | ||||
Publisher: | IEEE | ||||
Book Title: | 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) | ||||
Official Date: | 2015 | ||||
Dates: |
|
||||
Page Range: | pp. 147-152 | ||||
DOI: | 10.1109/3M-NANO.2015.7425498 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) | ||||
Type of Event: | Conference | ||||
Location of Event: | Changchun | ||||
Date(s) of Event: | 5-9 Oct 2015 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |