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Origins and progression of adolescent endometriosis

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Brosens, Ivo, Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, Jan J. and Benagiano, G. (2016) Origins and progression of adolescent endometriosis. Reproductive Sciences, 23 (10). pp. 1282-1288. doi:10.1177/1933719116637919 ISSN 1933-7191.

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Official URL: http://dx.doi.org/10.1177/1933719116637919

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Abstract

Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with earlyonset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Uterus -- Diseases, Uterus -- Blood-vessels, Menarche, Endometriosis
Journal or Publication Title: Reproductive Sciences
Publisher: Sage Publications, Inc.
ISSN: 1933-7191
Official Date: 1 October 2016
Dates:
DateEvent
1 October 2016Published
31 March 2016Available
Volume: 23
Number: 10
Page Range: pp. 1282-1288
DOI: 10.1177/1933719116637919
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 5 May 2016
Date of first compliant Open Access: 6 May 2016
Funder: National Health and Medical Research Council (Australia) (NHMRC)
Grant number: (1042298, CEG)

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