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Origins and progression of adolescent endometriosis
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Brosens, Ivo, Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, Jan J. and Benagiano, G. (2016) Origins and progression of adolescent endometriosis. Reproductive Sciences, 23 (10). pp. 1282-1288. doi:10.1177/1933719116637919
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Official URL: http://dx.doi.org/10.1177/1933719116637919
Abstract
Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with earlyonset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Uterus -- Diseases, Uterus -- Blood-vessels, Menarche, Endometriosis | ||||||
| Journal or Publication Title: | Reproductive Sciences | ||||||
| Publisher: | Sage Publications, Inc. | ||||||
| ISSN: | 1933-7191 | ||||||
| Official Date: | 1 October 2016 | ||||||
| Dates: |
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| Date of first compliant deposit: | 5 May 2016 | ||||||
| Volume: | 23 | ||||||
| Number: | 10 | ||||||
| Page Range: | pp. 1282-1288 | ||||||
| DOI: | 10.1177/1933719116637919 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | National Health and Medical Research Council (Australia) (NHMRC) | ||||||
| Grant number: | (1042298, CEG) |
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