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Origins and progression of adolescent endometriosis
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Brosens, Ivo, Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, Jan J. and Benagiano, G. (2016) Origins and progression of adolescent endometriosis. Reproductive Sciences . doi:10.1177/1933719116637919 (In Press)
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Official URL: http://dx.doi.org/10.1177/1933719116637919
Abstract
Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that
seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or
soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent
ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with earlyonset
endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an
increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology | ||||
| Library of Congress Subject Headings (LCSH): | Uterus -- Diseases, Uterus -- Blood-vessels, Menarche, Endometriosis | ||||
| Journal or Publication Title: | Reproductive Sciences | ||||
| Publisher: | Sage Publications, Inc. | ||||
| ISSN: | 1933-7191 | ||||
| Official Date: | 31 March 2016 | ||||
| Dates: |
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| DOI: | 10.1177/1933719116637919 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | In Press | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | National Health and Medical Research Council (Australia) (NHMRC) | ||||
| Grant number: | (1042298, CEG) |
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