Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease

Tools
- Tools
+ Tools

Plascencia-Villa, Germán, Ponce, Arturo, Collingwood, Joanna F., Arellano-Jiménez, M. Josefina, Zhu, Xiongwei, Rogers, Jack T., Betancourt, Israel, José-Yacamán, Miguel and Perry, George (2016) High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease. Scientific Reports, 6 . 24873. doi:10.1038/srep24873

[img]
Preview
PDF
WRAP_Scientific_Reports_2016_open_access.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (2667Kb) | Preview
Official URL: http://dx.doi.org/10.1038/srep24873

Request Changes to record.

Abstract

Abnormal accumulation of brain metals is a key feature of Alzheimer’s disease (AD). Formation of amyloid-β plaque cores (APC) is related to interactions with biometals, especially Fe, Cu and Zn, but their particular structural associations and roles remain unclear. Using an integrative set of advanced transmission electron microscopy (TEM) techniques, including spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM), nano-beam electron diffraction, electron holography and analytical spectroscopy techniques (EDX and EELS), we demonstrate that Fe in APC is present as iron oxide (Fe3O4) magnetite nanoparticles. Here we show that Fe was accumulated primarily as nanostructured particles within APC, whereas Cu and Zn were distributed through the amyloid fibers. Remarkably, these highly organized crystalline magnetite nanostructures directly bound into fibrillar Aβ showed characteristic superparamagnetic responses with saturated magnetization with circular contours, as observed for the first time by off-axis electron holography of nanometer scale particles.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH): Alzheimer's disease, Magnetite, Amyloid, Holography in medicine
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
Official Date: 28 April 2016
Dates:
DateEvent
28 April 2016Published
31 March 2016Accepted
4 March 2016Submitted
Date of first compliant deposit: 9 May 2016
Volume: 6
Article Number: 24873
DOI: 10.1038/srep24873
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Adapted As:

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us