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High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease
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Plascencia-Villa, Germán, Ponce, Arturo, Collingwood, Joanna F., Arellano-Jiménez, M. Josefina, Zhu, Xiongwei, Rogers, Jack T., Betancourt, Israel, José-Yacamán, Miguel and Perry, George (2016) High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease. Scientific Reports, 6 . 24873. doi:10.1038/srep24873
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Official URL: http://dx.doi.org/10.1038/srep24873
Abstract
Abnormal accumulation of brain metals is a key feature of Alzheimer’s disease (AD). Formation of amyloid-β plaque cores (APC) is related to interactions with biometals, especially Fe, Cu and Zn, but their particular structural associations and roles remain unclear. Using an integrative set of advanced transmission electron microscopy (TEM) techniques, including spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM), nano-beam electron diffraction, electron holography and analytical spectroscopy techniques (EDX and EELS), we demonstrate that Fe in APC is present as iron oxide (Fe3O4) magnetite nanoparticles. Here we show that Fe was accumulated primarily as nanostructured particles within APC, whereas Cu and Zn were distributed through the amyloid fibers. Remarkably, these highly organized crystalline magnetite nanostructures directly bound into fibrillar Aβ showed characteristic superparamagnetic responses with saturated magnetization with circular contours, as observed for the first time by off-axis electron holography of nanometer scale particles.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||
| Divisions: | Faculty of Science > Engineering | ||||||||
| Library of Congress Subject Headings (LCSH): | Alzheimer's disease, Magnetite, Amyloid, Holography in medicine | ||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 2045-2322 | ||||||||
| Official Date: | 28 April 2016 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 9 May 2016 | ||||||||
| Volume: | 6 | ||||||||
| Article Number: | 24873 | ||||||||
| DOI: | 10.1038/srep24873 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
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