Clark, Andrew J. (2016) Copper catalyzed atom transfer radical cyclization reactions. European Journal of Organic Chemistry, 2016 (13). pp. 2231-2243. doi:10.1002/ejoc.201501571 ISSN 1434-193X.

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Abstract

Atom transfer radical cyclization (ATRC) is a powerful technique to prepare functionalized 4–10 membered ring systems using transition metal catalysts. In this review recent advances in the use of copper complexes are described. In particular the effect of different ligands on reactivity, selectivity and product outcome are illustrated with application to heterocycle and natural product synthesis. New approaches that increase catalyst efficiency with supplemental reducing agents are reviewed and examples using green solvents, benign reducing agents (e.g. ascorbic acid) and with catalyst loadings as low as 0.05 mol-% are highlighted. Radical addition to aromatic rings and rearrangement reactions under ATRC conditions as well as application to radical-polar crossover reactions are also described.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Journal or Publication Title:	European Journal of Organic Chemistry
Publisher:	Wiley
ISSN:	1434-193X
Official Date:	May 2016
Dates:	Date Event May 2016 Published 14 March 2016 Available 17 February 2016 Accepted
Volume:	2016
Number:	13
Page Range:	pp. 2231-2243
DOI:	10.1002/ejoc.201501571
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	9 May 2016

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