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Perry, David, Momotenko, Dmitry, Lazenby, Robert A., Kang, Minkyung and Unwin, Patrick R. (2016) Characterization of nanopipettes. Analytical Chemistry . doi:10.1021/acs.analchem.6b01095
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Official URL: http://dx.doi.org/10.1021/acs.analchem.6b01095
Abstract
Nanopipettes are widely used in electrochemical and analytical techniques as tools for sizing, sequencing, sensing, delivery and imaging. For all of these applications, the response of a nanopipette is strongly affected by its geometry and surface chemistry. As the size of nanopipettes becomes smaller, precise geometric characterization is increasingly important, especially if nanopipette probes are to be used for quantitative studies and analysis. This contribution highlights the combination of data from voltage-scanning ion conductivity experiments, transmission electron microscopy (TEM) and finite element method (FEM) simulations to fully characterize nanopipette geometry and surface charge characteristics, with an accuracy not achievable using existing approaches. Indeed, it is shown that presently used methods for nanopipette characterization can lead to highly erroneous information on nanopipettes. The new approach to characterization further facilitates high-level quantification of the behavior of nanopipettes in electrochemical systems, as demonstrated herein for a scanning ion conductance microscope (SICM) setup.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | T Technology > TP Chemical technology | ||||||||||||
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC) |
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| Library of Congress Subject Headings (LCSH): | Nanotechnology -- Research, Electrochemical apparatus | ||||||||||||
| Journal or Publication Title: | Analytical Chemistry | ||||||||||||
| Publisher: | American Chemical Society | ||||||||||||
| ISSN: | 0003-2700 | ||||||||||||
| Official Date: | 17 May 2016 | ||||||||||||
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| Date of first compliant deposit: | 16 May 2016 | ||||||||||||
| DOI: | 10.1021/acs.analchem.6b01095 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| Copyright Holders: | ACS | ||||||||||||
| Funder: | European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), Marie Curie Intra-European Fellowship (IEF) | ||||||||||||
| Grant number: | 2009 AdG 247143-QUANTIFEP (ERC), EP/F500378/1 (EPSRC) 626158 FUNICIS (IEF) |
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