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Data for Spin-labelled photo-cytotoxic diazido platinum(IV) anticancer complex
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Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Data for Spin-labelled photo-cytotoxic diazido platinum(IV) anticancer complex. [Dataset]
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Plain Text (Read Me File describing additional data available)
README.txt - Supplemental Material Available under License Creative Commons Attribution Non-commercial Share Alike. Download (1896b) |
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Other (2D EPR dataset (field, time), comma separated plain text)
EPR_data.csv - Supplemental Material Available under License Creative Commons Attribution Non-commercial Share Alike. Download (455Kb) |
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Other (EPR spectral simulation, comma separated plain text)
Simulations.csv - Supplemental Material Available under License Creative Commons Attribution Non-commercial Share Alike. Download (24Kb) |
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Other (Time dependent spin adduct concentration data, comma separated plain text)
TimeDependentConcentration.csv - Supplemental Material Available under License Creative Commons Attribution Non-commercial Share Alike. Download (898b) |
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Other (2D EPR dataset, Bruker WinEPR binary file)
09Dec15_#18_X2.spc - Supplemental Material Available under License Creative Commons Attribution Non-commercial Share Alike. Download (240Kb) |
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Other (2D EPR dataset, Bruker WinEPR parameter file)
09Dec15_#18_X2.par - Supplemental Material Available under License Creative Commons Attribution Non-commercial Share Alike. Download (432b) |
Official URL: http://wrap.warwick.ac.uk/79055
Abstract
We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.
| Item Type: | Dataset | ||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics |
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| Type of Data: | EPR data, EasySpin simulation data | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Antineoplastic agents | ||||||||||||||||||
| Publisher: | University of Warwick, Department of Chemistry | ||||||||||||||||||
| Official Date: | May 2016 | ||||||||||||||||||
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| Status: | Not Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Media of Output (format): | .txt .csv | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Description: | 5 files of EPR data as described below Simulations.csv EasySpin generated simulation data, no scaling 3 columns, 1 header row EPR_data.csv Experimental data loaded from Bruker Binary with EasySpin 3 columns, 1 header row TimeDependentConcentration.csv Results of fitting spin adduct concentration as in Fig 3c 2 columns, 1 header row 09Dec15_#18_X2.par Raw bruker header and binary data files as generated |
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