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Cardiolipin interactions with proteins
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Planas-Iglesias, Joan, Dwarakanath, Himal, Mohammadyani, Dariush, Yanamala, Naveena, Kagan, Valerian E and Klein-Seetharaman, Judith (2015) Cardiolipin interactions with proteins. Biophysical Journal, 109 (6). pp. 1282-94. doi:10.1016/j.bpj.2015.07.034
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Official URL: http://dx.doi.org/10.1016/j.bpj.2015.07.034
Abstract
Cardiolipins (CL) represent unique phospholipids of bacteria and eukaryotic mitochondria with four acyl chains and two phosphate groups that have been implicated in numerous functions from energy metabolism to apoptosis. Many proteins are known to interact with CL, and several cocrystal structures of protein-CL complexes exist. In this work, we describe the collection of the first systematic and, to the best of our knowledge, the comprehensive gold standard data set of all known CL-binding proteins. There are 62 proteins in this data set, 21 of which have nonredundant crystal structures with bound CL molecules available. Using binding patch analysis of amino acid frequencies, secondary structures and loop supersecondary structures considering phosphate and acyl chain binding regions together and separately, we gained a detailed understanding of the general structural and dynamic features involved in CL binding to proteins. Exhaustive docking of CL to all known structures of proteins experimentally shown to interact with CL demonstrated the validity of the docking approach, and provides a rich source of information for experimentalists who may wish to validate predictions.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biophysical Journal | ||||||||||
| Publisher: | Biophysical Society | ||||||||||
| ISSN: | 0006-3495 | ||||||||||
| Official Date: | 15 September 2015 | ||||||||||
| Dates: |
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| Volume: | 109 | ||||||||||
| Number: | 6 | ||||||||||
| Page Range: | pp. 1282-94 | ||||||||||
| DOI: | 10.1016/j.bpj.2015.07.034 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Funder: | International Human Frontier Science Program Organization, National Institutes of Health (U.S.) (NIH) | ||||||||||
| Grant number: | HFSP-RGP0013/2014 |
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