The Library
Extending signaling pathways with protein-interaction networks. Application to apoptosis
Tools
Planas-Iglesias, Joan, Guney, Emre, Garcia-Garcia, Javier, Robertson, Kevin A., Raza, Sobia, Freeman, Tom C., Ghazal, Peter and Oliva, Baldo (2012) Extending signaling pathways with protein-interaction networks. Application to apoptosis. OMICS A Journal of Integrative Biology, 16 (5). pp. 245-256. doi:10.1089/omi.2011.0130 ISSN 1536-2310.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1089/omi.2011.0130.
Abstract
Cells exploit signaling pathways during responses to environmental changes, and these processes are often modulated during disease. Particularly, relevant human pathologies such as cancer or viral infections require downregulating apoptosis signaling pathways to progress. As a result, the identification of proteins responsible for these changes is essential for the diagnostics and development of therapeutics. Transferring functional annotation within protein interaction networks has proven useful to identify such proteins, although this is not a trivial task. Here, we used different scoring methods to transfer annotation from 53 well-studied members of the human apoptosis pathways (as known by 2005) to their protein interactors. All scoring methods produced significant predictions (compared to a random negative model), but its number was too large to be useful. Thus, we made a final prediction using specific combinations of scoring methods and compared it to the proteins related to apoptosis signaling pathways during the last 5 years. We propose 273 candidate proteins that may be relevant in apoptosis signaling pathways. Although some of them have known functions consistent with their proposed apoptotsis involvement, the majority have not been annotated yet, leaving room for further experimental studies. We provide our predictions at http://sbi.imim.es/web/Apoptosis.php.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | OMICS A Journal of Integrative Biology | ||||
Publisher: | Mary Ann Liebert, Inc. Publishers | ||||
ISSN: | 1536-2310 | ||||
Official Date: | 2012 | ||||
Dates: |
|
||||
Volume: | 16 | ||||
Number: | 5 | ||||
Page Range: | pp. 245-256 | ||||
DOI: | 10.1089/omi.2011.0130 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |