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iLoops : a protein-protein interaction prediction server based on structural features
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Planas-Iglesias, Joan, Marin-Lopez, Manuel A., Bonet, Jaume, Garcia-Garcia, Javier and Oliva, Baldo (2013) iLoops : a protein-protein interaction prediction server based on structural features. Bioinformatics, 29 (18). pp. 2360-2362. doi:10.1093/bioinformatics/btt401 ISSN 1367-4803.
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Official URL: http://dx.doi.org/10.1093/bioinformatics/btt401
Abstract
Summary: Protein–protein interactions play a critical role in many biological
processes. Despite that, the number of servers that provide an
easy and comprehensive method to predict them is still limited. Here,
we present iLoops, a web server that predicts whether a pair of proteins
can interact using local structural features. The inputs of the
server are as follows: (i) the sequences of the query proteins and (ii)
the pairs to be tested. Structural features are assigned to the query
proteins by sequence similarity. Pairs of structural features (formed by
loops or domains) are classified according to their likelihood to favor or
disfavor a protein–protein interaction, depending on their observation
in known interacting and non-interacting pairs. The server evaluates
the putative interaction using a random forest classifier.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Bioinformatics | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 1367-4803 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | 29 | ||||
Number: | 18 | ||||
Page Range: | pp. 2360-2362 | ||||
DOI: | 10.1093/bioinformatics/btt401 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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