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Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources
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Nev, Olga and Berg, Hugo van den (2017) Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources. Journal of Mathematical Biology, 74 (1-2). pp. 409-445. doi:10.1007/s00285-016-1030-4
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Official URL: http://dx.doi.org/10.1007/s00285-016-1030-4
Abstract
Variable-Internal-Stores models of microbial metabolism and growth have proven to be invaluable in accounting for changes in cellular composition as microbial cells adapt to varying conditions of nutrient availability. Here, such a model is extended with explicit allocation of molecular building blocks among various types of catalytic machinery. Such an extension allows a reconstruction of the regulatory rules employed by the cell as it adapts its physiology to changing environmental conditions. Moreover, the extension proposed here creates a link between classic models of microbial growth and analyses based on detailed transcriptomics and proteomics data sets. We ascertain the compatibility between the extended Variable-Internal-Stores model and the classic models, demonstrate its behaviour by means of simulations, and provide a detailed treatment of the uniqueness and the stability of its equilibrium point as a function of the availabilities of the various nutrients
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QR Microbiology | ||||||||
| Divisions: | Faculty of Science > Mathematics | ||||||||
| Library of Congress Subject Headings (LCSH): | Microbial growth, Microbial metabolism, Cell physiology, Proteomics | ||||||||
| Journal or Publication Title: | Journal of Mathematical Biology | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 0303-6812 | ||||||||
| Official Date: | January 2017 | ||||||||
| Dates: |
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| Volume: | 74 | ||||||||
| Number: | 1-2 | ||||||||
| Number of Pages: | 37 | ||||||||
| Page Range: | pp. 409-445 | ||||||||
| DOI: | 10.1007/s00285-016-1030-4 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Seventh Framework Programme (European Commission) (FP7), Marie Skłodowska-Curie actions |
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