Thompson, Andrew D., Marwaha, Steven, Nelson, Barnaby, Wood, Stephen J., McGorry, Patrick D., Yung, Alison R. and Lin, Ashleigh (2016) Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort? Psychiatry research, 236 . pp. 182-185. doi:10.1016/j.psychres.2016.01.017

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Abstract

We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate if this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Psychiatry research
Publisher:	Elsevier Ireland Ltd.
ISSN:	0165-1781
Official Date:	February 2016
Dates:	Date Event February 2016 Published 8 January 2016 Available 6 January 2016 Accepted 24 September 2015 Submitted
Volume:	236
Page Range:	pp. 182-185
DOI:	10.1016/j.psychres.2016.01.017
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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