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Cannabis use is associated with increased psychotic symptoms and poorer psychosocial functioning in first-episode psychosis : a report from the UK National EDEN study

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Seddon, Jennifer L., Birchwood, M. J., Copello, Alex, Everard, Linda, Jones, Peter B., Fowler, David, Amos, Tim, Freemantle, Nick, Sharma, Vimal, Marshall, Max and Singh, Swaran P. (2016) Cannabis use is associated with increased psychotic symptoms and poorer psychosocial functioning in first-episode psychosis : a report from the UK National EDEN study. Schizophrenia Bulletin, 42 (3). pp. 619-625. doi:10.1093/schbul/sbv154 ISSN 0586-7614.

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Official URL: http://dx.doi.org/10.1093/schbul/sbv154

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Abstract

Objective: The use of cannabis during the early stage of psychosis has been linked with increased psychotic symptoms. This study aimed to examine the use of cannabis in the 12 months following a first-episode of psychosis (FEP) and the link with symptomatic course and outcome over 1 year post psychosis onset.

Design and Setting: One thousand twenty-seven FEP patients were recruited upon inception to specialized early intervention services (EIS) for psychosis in the United Kingdom. Participants completed assessments at baseline, 6 and 12 months.

Results: The results indicate that the use of cannabis was significantly associated with increased severity of psychotic symptoms, mania, depression and poorer psychosocial functioning. Continued use of cannabis following the FEP was associated with poorer outcome at 1 year for Positive and Negative Syndrome Scale total score, negative psychotic symptoms, depression and psychosocial functioning, an effect not explained by age, gender, duration of untreated psychosis, age of psychosis onset, ethnicity or other substance use.

Conclusion: This is the largest cohort study of FEP patients receiving care within EIS. Cannabis use, particularly “continued use,” was associated with poorer symptomatic and functional outcome during the FEP. The results highlight the need for effective and early intervention for cannabis use in FEP.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Schizophrenia Bulletin
Publisher: Oxford University Press
ISSN: 0586-7614
Official Date: 3 May 2016
Dates:
DateEvent
3 May 2016Published
4 November 2015Available
6 September 2015Accepted
Volume: 42
Number: 3
Page Range: pp. 619-625
DOI: 10.1093/schbul/sbv154
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)

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