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A hydrogel based localized release of colistin for antimicrobial treatment of burn wound infection
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Zhu, Chongyu, Jinxin, Zhao, Kempe, Kristian, Wilson, Paul, Wang, Jiping , Velkov, Tony , Li, Jian , Davis, Thomas P., Whittaker, Michael R. and Haddleton, David M. (2016) A hydrogel based localized release of colistin for antimicrobial treatment of burn wound infection. Macromolecular Bioscience, 17 (2). 1600320. doi:10.1002/mabi.201600320 ISSN 1616-5187.
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Official URL: http://dx.doi.org/10.1002/mabi.201600320
Abstract
There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug-resistant (MDR) Gram-negative ‘superbugs’, especially the problematic Pseudomonas aeruginosa. In this work we report the incorporation of colistin, a potent lipopeptide into a self-healable hydrogel (via dynamic imine bond formation) following the chemical reaction between the amine groups present in glycol chitosan and an aldehyde modified poly (ethylene glycol) (PEG). The storage module (G’) of the colistin-loaded hydrogel ranged from 1.3 kPa to 5.3 kPa by varying the amount of the cross-linker and colistin loading providing different options for topical wound healing. The majority of the colistin is released from the hydrogel within 24 h and remains active as demonstrated by both antibacterial in vitro disk diffusion and time-kill assays. Moreover and pleasingly, the colistin-loaded hydrogel performed almost equally well as native colistin against both the colistin-sensitive and also colistin-resistant P. aeruginosa strain in the in vivo animal 'burn' infection model despite exhibiting a slower killing profile in vitro. Based on this antibiotic performance along with the biodegradability of the product, we believe the colistin-loaded hydrogel to be a potential localized wound-healing formulation to treat burn wounds against microbial infection.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Colloids, Burns and scalds -- Treatment, Wounds and injuries -- Treatment, Anti-infective agents | |||||||||||||||
Journal or Publication Title: | Macromolecular Bioscience | |||||||||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | |||||||||||||||
ISSN: | 1616-5187 | |||||||||||||||
Official Date: | 13 September 2016 | |||||||||||||||
Dates: |
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Volume: | 17 | |||||||||||||||
Number: | 2 | |||||||||||||||
Article Number: | 1600320 | |||||||||||||||
DOI: | 10.1002/mabi.201600320 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 17 August 2016 | |||||||||||||||
Date of first compliant Open Access: | 23 February 2017 | |||||||||||||||
Grant number: | Project No. | |||||||||||||||
RIOXX Funder/Project Grant: |
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