The Library
Asymmetric synthesis of 2-substituted Azetidin-3-ones via metalated SAMP/RAMP hydrazones
Tools
Tools
Tools
Pancholi, Alpa K., Geden, Joanna V., Clarkson, Guy J. and Shipman, Michael (2016) Asymmetric synthesis of 2-substituted Azetidin-3-ones via metalated SAMP/RAMP hydrazones. Journal of Organic Chemistry . doi:10.1021/acs.joc.6b01284 (In Press)
|
PDF
WRAP_acs%2Ejoc%2E6b01284.pdf - Accepted Version - Requires a PDF viewer. Download (683Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acs.joc.6b01284
Abstract
2-Substituted azetidin-3-ones can be prepared in good yields and enantioselectivities (up to 85% ee) by a one-pot procedure involving the metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one, reaction with a wide range of electrophiles, including alkyl, allyl and benzyl halides and carbonyl compounds, followed by hydrolysis using oxalic acid.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology | ||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Drug development | ||||||||
| Journal or Publication Title: | Journal of Organic Chemistry | ||||||||
| Publisher: | American Chemical Society | ||||||||
| ISSN: | 0022-3263 | ||||||||
| Official Date: | 22 July 2016 | ||||||||
| Dates: |
|
||||||||
| Date of first compliant deposit: | 25 July 2016 | ||||||||
| DOI: | 10.1021/acs.joc.6b01284 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | In Press | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), University of Warwick |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
