Playford, E. Diane, Britton, T. C., Thompson, P. D., Brooks, D. J., Findley, L. J. and Marsden, C. D. (1995) Exacerbation of postural tremor with emergence of parkinsonism after treatment with neuroleptic drugs. Journal of Neurology, Neurosurgery and Psychiatry, 58 (4). pp. 487-489. doi:10.1136/jnnp.58.4.487 ISSN 0022-3050.

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Abstract

Neuroleptic medication in three patients with prior isolated postural arm tremor led to a conspicuous deterioration; the postural tremor increased in amplitude, tremor appeared at rest, and other signs of mild parkinsonism developed. Withdrawal of neuroleptic drugs led to improvement in tremor and disappearance of parkinsonism. Positron emission tomography showed no reduction in uptake of [18F]dopa into nigrostriatal terminals suggesting that these patients did not have Parkinson's disease. Neuroleptic drugs can convert postural essential arm tremor into that characteristic of Parkinson's disease in patients with no evident nigrostriatal lesion.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Neurology, Neurosurgery and Psychiatry
Publisher:	B M J Group
ISSN:	0022-3050
Official Date:	April 1995
Dates:	Date Event April 1995 Published
Volume:	58
Number:	4
Page Range:	pp. 487-489
DOI:	10.1136/jnnp.58.4.487
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Open Access Version:	Publisher PubMed Central

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