The Library
Striatal 18Fdopa uptake in familial idiopathic dystonia
Tools
Tools
Tools
Playford, E. Diane, Fletcher, N. A., Sawle, G. V. , Marsden, C. D. and Brooks, D. J. (1993) Striatal 18Fdopa uptake in familial idiopathic dystonia. Brain, 116 (Part 5). pp. 1191-1199. 8221055. doi:10.1093/brain/116.5.1191 ISSN 0006-8950.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1093/brain/116.5.1191
Abstract
It is known that most cases of idiopathic torsion dystonia (ITD) are inherited in an autosomal dominant fashion. Despite clarification of the underlying genetic defect, no consistent structural lesion has been identified in ITD, and it is probable that a biochemical disturbance is the basis of the disorder. To determine whether there is impaired function of the nigro-striatal dopaminergic terminals in ITD we studied 11 subjects with generalized ITD and a positive family history using [18F]dopa and PET scanning. Of these 11 patients, eight had putamen [18F]dopa uptake within the lower half of the normal range, while three had uptake reduced by > 2 SDs below the normal mean. The lowest putamen [18F]dopa influx constants were found in the most disabled patients. As these reductions were mild it is unlikely that abnormalities of the nigro-striatal dopaminergic pathway are the primary determinant of either the nature of the severity of dystonic symptoms. In addition, we studied three presumed carriers of the ITD gene. These subjects all had normal striatal [18F]dopa influx constants suggesting that [18F]dopa PET is unsuitable as a screening tool for ITD.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
| Journal or Publication Title: | Brain | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 0006-8950 | ||||
| Official Date: | 1993 | ||||
| Dates: |
|
||||
| Volume: | 116 | ||||
| Number: | Part 5 | ||||
| Page Range: | pp. 1191-1199 | ||||
| Article Number: | 8221055 | ||||
| DOI: | 10.1093/brain/116.5.1191 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
