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Asymmetrical pre-synaptic and post-synaptic changes in the striatal dopamine projection in dopa naive parkinsonism. Diagnostic implications of the D2 receptor status
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Sawle, G. V. , Playford, E. Diane, Brooks, D. J., Quinn, N. P. and Frackowiak, R. S. J. (1993) Asymmetrical pre-synaptic and post-synaptic changes in the striatal dopamine projection in dopa naive parkinsonism. Diagnostic implications of the D2 receptor status. Brain, 116 (Part 4). pp. 853-867. 8353712. doi:doi: 10.1093/brain/116.4.853 853-867 ISSN 0006-8950.
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Official URL: http://dx.doi.org/10.1093/brain/116.4.853 853-867
Abstract
Nine L-dopa na ve patients with clinically diagnosed parkinsonism were studied using positron emission tomography with 6-L-[18F]fluorodopa ([18F]dopa, a pre-synaptic tracer) and [11C]raclopride (which binds to D2 receptors). Putamen [18F]dopa uptake was reduced in all patients, confirming a loss of function affecting the nigrostriatal projection. In eight patients the putamen with the lowest [18F]dopa uptake (always contralateral to the clinically most affected side) had the highest [11C]raclopride binding, suggesting upregulation of the post-synaptic D2 receptors. In the ninth patient [11C]raclopride binding was lower in the putamen with the lowest [18F]dopa uptake, indicating an additional post-synaptic deficit. All nine patients were shown to be L-dopa responsive. The subsequent clinical course of the former eight patients has been typical of idiopathic Parkinson's disease, whilst the ninth patient has developed postural hypotension, urinary incontinence and respiratory stridor typical of multiple system atrophy. Reduced [11C]raclopride binding in L-dopa naïve parkinsonian patients might serve as a useful early marker of this condition.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) | ||||
| Journal or Publication Title: | Brain | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 0006-8950 | ||||
| Official Date: | 1993 | ||||
| Dates: |
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| Volume: | 116 | ||||
| Number: | Part 4 | ||||
| Page Range: | pp. 853-867 | ||||
| Article Number: | 8353712 | ||||
| DOI: | doi: 10.1093/brain/116.4.853 853-867 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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