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Presynaptic and postsynaptic striatal dopaminergic function in neuroacanthocytosis : a positron emission tomographic study
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Brooks, D. J., Ibanez, V., Playford, E. Diane, Sawle, G. V. , Leigh, P. N. , Kocen, R. S., Harding, A. E. and Marsden, C. D. (1991) Presynaptic and postsynaptic striatal dopaminergic function in neuroacanthocytosis : a positron emission tomographic study. Annals of Neurology, 30 (2). pp. 166-171. ISSN 0364-5134.
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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/1897909
Abstract
Using [18F]dopa, [11C]raclopride, C15O2, and positron emission tomography, we have assessed striatal dopamine storage capacity, dopamine D2-receptor integrity, and regional cerebral blood flow, respectively, of 6 patients with neuroacanthocytosis. The patients with neurocanthocytosis all had chorea and variable combinations of seizures, dementia, axonal neuropathy, and orolingual self-multiation. [18F]dopa positron emmission tomographic findings were compared with 30 normal controls and 16 patients with sporadic, L-dopa-responsive, Parkinson's disease. Caudate and anterior putamen [18F]dopa uptake were normal in patients with neuroacanthocytosis, but mean posterior putamen [18F]dopa uptake was reduced to 42% of normal, similar to that in patients with Parkinson's disease. In patients with neuroacanthocytosis, mean equilibrium caudate: cerebellum and putamen: cerebellum [11C]raclopride uptake ratios were reduced to 54% and 62% of normal, compatible with a 65% and 53% loss of caudate and putamen D2-receptor-binding sites, respectively. Striatal and frontal blood flow was also depressed. The severe loss of D2-receptor-bearing striatal neuron, with concomitant loss of dopaminergic projections from the nigra to the posterior putamen, is consistent with both chorea and extrapyramidal rigidity being features of patients with neuroacanthocytosis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Annals of Neurology | ||||
| Publisher: | John Wiley & Sons, Inc. | ||||
| ISSN: | 0364-5134 | ||||
| Official Date: | 1991 | ||||
| Dates: |
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| Volume: | 30 | ||||
| Number: | 2 | ||||
| Page Range: | pp. 166-171 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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