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The association of children’s mathematic abilities with both adults’ cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals
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Bäuml, Josef G., Meng, Chun, Daamen, Marcel, Baumann, Nicole, Busch, Barbara, Bartmann, Peter, Wolke, Dieter, Boecker, Henning, Wohlschläger, Afra, Sorg, Christian and Jaekel, Julia (2017) The association of children’s mathematic abilities with both adults’ cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals. Brain Structure and Function, 222 (2). pp. 799-812. doi:10.1007/s00429-016-1247-4
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Official URL: http://dx.doi.org/10.1007/s00429-016-1247-4
Abstract
Mathematic abilities in childhood are highly predictive for long-term neurocognitive outcomes. Preterm-born individuals have an increased risk for both persistent cognitive impairments and long-term changes in macroscopic brain organization. We hypothesized that the association of childhood mathematic abilities with both adulthood general cognitive abilities and associated fronto-parietal intrinsic networks is altered after preterm delivery. 72 preterm- and 71 term-born individuals underwent standardized mathematic and IQ testing at 8 years and resting-state fMRI and full-scale IQ testing at 26 years of age. Outcome measure for intrinsic networks was intrinsic functional connectivity (iFC). Controlling for IQ at age eight, mathematic abilities in childhood were significantly stronger positively associated with adults’ IQ in preterm compared with term-born individuals. In preterm-born individuals, the association of children’s mathematic abilities and adults’ fronto-parietal iFC was altered. Likewise, fronto-parietal iFC was distinctively linked with preterm- and term-born adults’ IQ. Results provide evidence that preterm birth alters the link of mathematic abilities in childhood and general cognitive abilities and fronto-parietal intrinsic networks in adulthood. Data suggest a distinct functional role of intrinsic fronto-parietal networks for preterm individuals with respect to mathematic abilities and that these networks together with associated children’s mathematic abilities may represent potential neurocognitive targets for early intervention.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RJ Pediatrics | ||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Premature infants, Mathematical ability | ||||||||
| Journal or Publication Title: | Brain Structure and Function | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 1863-2653 | ||||||||
| Official Date: | March 2017 | ||||||||
| Dates: |
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| Volume: | 222 | ||||||||
| Number: | 2 | ||||||||
| Page Range: | pp. 799-812 | ||||||||
| DOI: | 10.1007/s00429-016-1247-4 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Deutsche Forschungsgemeinschaft (DFG), Germany. Bundesministerium für Bildung und Forschung (BMBF), Universität München. Kommission für Klinische Forschung, Technische | ||||||||
| Grant number: | JA 1913/2-1 (DFG), 01ER0801 (BMBF), 01EV0710 (BMBF), 01ER0803 (BMBF), 8765162 (KKF) |
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