Bäuml, Josef G., Meng, Chun, Daamen, Marcel, Baumann, Nicole, Busch, Barbara, Bartmann, Peter, Wolke, Dieter, Boecker, Henning, Wohlschläger, Afra, Sorg, Christian and Jaekel, Julia (2017) The association of children’s mathematic abilities with both adults’ cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals. Brain Structure and Function, 222 (2). pp. 799-812. doi:10.1007/s00429-016-1247-4

Preview	PDF WRAP_manuscript_maths_iq8_buml_final_re-re-revised_1.pdf - Accepted Version - Requires a PDF viewer. Download (913Kb) | Preview
Preview	PDF WRAP_buml_et_al__2015._supplemental_material_math_iq8_re-re-revised_1.pdf - Supplemental Material - Requires a PDF viewer. Download (519Kb) | Preview
Preview	Image (TIFF) WRAP_0671038-ps-170616-figure-i.tif - Supplemental Material Download (1689Kb) | Preview
Preview	Image (TIFF) 0671038-ps-170616-figure-ii_revised.tiff - Supplemental Material Download (14Mb) | Preview

Request Changes to record.

Abstract

Mathematic abilities in childhood are highly predictive for long-term neurocognitive outcomes. Preterm-born individuals have an increased risk for both persistent cognitive impairments and long-term changes in macroscopic brain organization. We hypothesized that the association of childhood mathematic abilities with both adulthood general cognitive abilities and associated fronto-parietal intrinsic networks is altered after preterm delivery. 72 preterm- and 71 term-born individuals underwent standardized mathematic and IQ testing at 8 years and resting-state fMRI and full-scale IQ testing at 26 years of age. Outcome measure for intrinsic networks was intrinsic functional connectivity (iFC). Controlling for IQ at age eight, mathematic abilities in childhood were significantly stronger positively associated with adults’ IQ in preterm compared with term-born individuals. In preterm-born individuals, the association of children’s mathematic abilities and adults’ fronto-parietal iFC was altered. Likewise, fronto-parietal iFC was distinctively linked with preterm- and term-born adults’ IQ. Results provide evidence that preterm birth alters the link of mathematic abilities in childhood and general cognitive abilities and fronto-parietal intrinsic networks in adulthood. Data suggest a distinct functional role of intrinsic fronto-parietal networks for preterm individuals with respect to mathematic abilities and that these networks together with associated children’s mathematic abilities may represent potential neurocognitive targets for early intervention.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Premature infants, Mathematical ability
Journal or Publication Title:	Brain Structure and Function
Publisher:	Springer
ISSN:	1863-2653
Official Date:	March 2017
Dates:	Date Event March 2017 Published 13 June 2016 Available 5 June 2016 Accepted
Date of first compliant deposit:	17 June 2016
Volume:	222
Number:	2
Page Range:	pp. 799-812
DOI:	10.1007/s00429-016-1247-4
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Deutsche Forschungsgemeinschaft (DFG), Germany. Bundesministerium für Bildung und Forschung (BMBF), Universität München. Kommission für Klinische Forschung, Technische
Grant number:	JA 1913/2-1 (DFG), 01ER0801 (BMBF), 01EV0710 (BMBF), 01ER0803 (BMBF), 8765162 (KKF)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item

Downloads