The Library
A simple breath test for tuberculosis using ion mobility : a pilot study
Tools
Tools
Tools
Sahota, Amandip S., Gowda, Ravi, Arasaradnam, Ramesh P., Daulton, Emma, Savage, Richard S., Skinner, Jim R., Adams, Emily, Ward, Stephen A. and Covington, James A. (2016) A simple breath test for tuberculosis using ion mobility : a pilot study. Tuberculosis, 99 . pp. 143-146. doi:10.1016/j.tube.2016.05.005 ISSN 1472-9792.
|
PDF
WRAP_1-s2.0-S147297921630110X-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (666Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.tube.2016.05.005
Abstract
Tuberculosis (TB) remains one of the world's major health burdens with 9.6 million new infections globally. Though considerable progress has been made in reduction of TB incidence and mortality, there is a continuous need for lower cost, simpler and more robust means of diagnosis. One method that may fulfil these requirements is in the area of breath analysis. In this study we analysed the breath of 21 patients with pulmonary or extra-pulmonary TB, recruited from a UK teaching hospital (University Hospital Coventry and Warwickshire) before or within 1 week of commencing treatment for TB. TB diagnosis was confirmed by reference tests (mycobacterial culture), histology or radiology. 19 controls were recruited to calculate specificity; these patients were all interferon-gamma release assay negative (T.SPOT®.TB, Oxford Immunotec Ltd.). Whole breath samples were collected with subsequent chemical analysis undertaken by Ion Mobility Spectrometry. Our results produced a sensitivity of 81% and a specificity of 79% for all cases of TB (pulmonary and extra-pulmonary). Though lower than other studies analysing pulmonary TB alone, we believe that this technique shows promise, and a higher sensitivity could be achieved by further improving our sample capture methodology.
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Centre for Complexity Science Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||
| Library of Congress Subject Headings (LCSH): | Tuberculosis -- Diagnosis, Breath testing, Mycobacterial diseases, Ion mobility spectroscopy | ||||||||||
| Journal or Publication Title: | Tuberculosis | ||||||||||
| Publisher: | Churchill Livingstone | ||||||||||
| ISSN: | 1472-9792 | ||||||||||
| Official Date: | July 2016 | ||||||||||
| Dates: |
|
||||||||||
| Volume: | 99 | ||||||||||
| Page Range: | pp. 143-146 | ||||||||||
| DOI: | 10.1016/j.tube.2016.05.005 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Date of first compliant deposit: | 29 June 2016 | ||||||||||
| Date of first compliant Open Access: | 29 June 2016 | ||||||||||
| RIOXX Funder/Project Grant: |
|
||||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
