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A simple breath test for tuberculosis using ion mobility : a pilot study

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Sahota, Amandip S., Gowda, Ravi, Arasaradnam, Ramesh P., Daulton, Emma, Savage, Richard S., Skinner, Jim R., Adams, Emily, Ward, Stephen A. and Covington, James A. (2016) A simple breath test for tuberculosis using ion mobility : a pilot study. Tuberculosis, 99 . pp. 143-146. doi:10.1016/j.tube.2016.05.005 ISSN 1472-9792.

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Official URL: http://dx.doi.org/10.1016/j.tube.2016.05.005

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Abstract

Tuberculosis (TB) remains one of the world's major health burdens with 9.6 million new infections globally. Though considerable progress has been made in reduction of TB incidence and mortality, there is a continuous need for lower cost, simpler and more robust means of diagnosis. One method that may fulfil these requirements is in the area of breath analysis. In this study we analysed the breath of 21 patients with pulmonary or extra-pulmonary TB, recruited from a UK teaching hospital (University Hospital Coventry and Warwickshire) before or within 1 week of commencing treatment for TB. TB diagnosis was confirmed by reference tests (mycobacterial culture), histology or radiology. 19 controls were recruited to calculate specificity; these patients were all interferon-gamma release assay negative (T.SPOT®.TB, Oxford Immunotec Ltd.). Whole breath samples were collected with subsequent chemical analysis undertaken by Ion Mobility Spectrometry. Our results produced a sensitivity of 81% and a specificity of 79% for all cases of TB (pulmonary and extra-pulmonary). Though lower than other studies analysing pulmonary TB alone, we believe that this technique shows promise, and a higher sensitivity could be achieved by further improving our sample capture methodology.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Research Centres > Centre for Complexity Science
Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Tuberculosis -- Diagnosis, Breath testing, Mycobacterial diseases, Ion mobility spectroscopy
Journal or Publication Title: Tuberculosis
Publisher: Churchill Livingstone
ISSN: 1472-9792
Official Date: July 2016
Dates:
DateEvent
July 2016Published
29 May 2016Available
22 May 2016Accepted
18 March 2016Submitted
Volume: 99
Page Range: pp. 143-146
DOI: 10.1016/j.tube.2016.05.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 29 June 2016
Date of first compliant Open Access: 29 June 2016
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MC_PC_13069Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
EP/IO1358X/1 [EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
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