Leng, Y., Cappuccio, Francesco, Surtees, P. G., Luben, R., Brayne, C. and Khaw, K.-T. (2016) Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population. Nutrition, Metabolism and Cardiovascular Diseases, 26 (11). pp. 996-1003. ISSN 0939-4753.

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Abstract

Background and aims: Few studies have prospectively examined the relationship between daytime napping and risk of type 2 diabetes. We aimed to study the effects of daytime napping and the joint effects of napping and sleep duration in predicting type 2 diabetes risk in a middle- to older-aged British population.
Methods and results: In 1998-2000, 13465 individuals with no known diabetes participating in the European Prospective Investigation into Cancer-Norfolk study reported daytime napping habit and 24-h sleep duration. Incident type 2 diabetes cases were identified through multiple data sources until 31 July 2006. After adjustment for age and sex, daytime napping was associated with a 58% higher diabetes risk. Further adjustment for education, marital status, smoking, alcohol intake, physical activity, comorbidities and hypnotic drug use had little influence on the association, but additional adjustment for BMI and Waist Circumference attenuated the Odds ratio (OR) (95%CI) to 1.30 (1.01, 1.69). The adjusted ORs (95%CI) associated with short and long sleep duration were 1.46 (1.10, 1.90) and 1.64 (1.16, 2.32), respectively. When sleep duration and daytime napping were examined together, the risk of developing diabetes more than doubled for those who took day naps and had less than 6h of sleep, compared to those who did not nap and had 6-8h of sleep.
Conclusion: Daytime napping was associated with an increased risk of type 2 diabetes, particularly when combined with short sleep duration. Further physiological studies are needed to confirm the interaction between different domains of sleep in relation to diabetes risk.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Naps (Sleep) , Non-insulin-dependent diabetes -- Diagnosis, Epidemiology
Journal or Publication Title:	Nutrition, Metabolism and Cardiovascular Diseases
Publisher:	Elsevier Ltd
ISSN:	0939-4753
Official Date:	28 June 2016
Dates:	Date Event 28 June 2016 Available 17 June 2016 Accepted 21 March 2016 Submitted
Volume:	26
Number:	11
Page Range:	pp. 996-1003
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	29 June 2016
Date of first compliant Open Access:	29 September 2016
Funder:	Medical Research Council (Great Britain) (MRC), Cancer Research UK (CRUK)
Grant number:	G9502233, G0300128 (Great Britain) (MRC), C865/A2883 (CRUK)
Open Access Version:	Publisher

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