Winsper, Catherine, Marwaha, Steven, Lereya, Suzet Tanya, Thompson, Andrew David, Eyden, Julie and Singh, Swaran P. (2016) A systematic review of the neurobiological underpinnings of borderline personality disorder (BPD) in childhood and adolescence. Reviews in the Neurosciences, 27 (8). pp. 827-847. doi:10.1515/revneuro-2016-0026 ISSN 0334-1763 .

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Abstract

Contemporary theories for the aetiology of borderline personality disorder (BPD) take a lifespan approach asserting that inborn biological predisposition is potentiated across development by environmental risk factors. In this review, we present and critically evaluate evidence on the neurobiology of BPD in childhood and adolescence, compare this evidence to the adult literature, and contextualise within a neurodevelopmental framework. A systematic review was conducted to identify studies examining the neurobiological (i.e. genetic, structural neuroimaging, neurophysiological, and neuropsychological) correlates of BPD symptoms in children and adolescents aged 19 years or under. We identified, quality assessed, and narratively summarised 34 studies published between 1980 and June 2016. Similar to findings in adult populations, twin studies indicated moderate to high levels of heritability of BPD, and there was some evidence for gene-environment interactions. Also consistent with adult reports is that some adolescents with BPD demonstrated structural (grey and white matter) alterations in frontolimbic regions and neuropsychological abnormalities (i.e. reduced executive function and disturbances in social cognition). These findings suggest that neurobiological abnormalities observed in adult BPD may not solely be the consequence of chronic morbidity or prolonged medication use. They also provide tentative support for neurodevelopmental theories of BPD by demonstrating that neurobiological markers may be observed from childhood onwards and interact with environmental factors to increase risk of BPD in young populations. Prospective studies with a range of repeated measures are now required to elucidate the temporal unfurling of neurobiological features and further delineate the complex pathways to BPD.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Borderline personality disorder in children, Neurobiology
Journal or Publication Title:	Reviews in the Neurosciences
Publisher:	Walter de Gruyter GmbH
ISSN:	0334-1763
Official Date:	1 December 2016
Dates:	Date Event 1 December 2016 Published 12 August 2016 Available 2 July 2016 Accepted 3 May 2016 Submitted
Volume:	27
Number:	8
Page Range:	pp. 827-847
DOI:	10.1515/revneuro-2016-0026
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	5 July 2016
Date of first compliant Open Access:	19 April 2018
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED National Institute for Health Research http://dx.doi.org/10.13039/501100000272
Related URLs:	Publisher

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