The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response
Akande, Valentine A., Keay, Stephen D., Hunt, Linda P., Mathur, Rajneesh, Jenkins, Julian M. and Cahill, David J.. (2005) The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response. Journal of Assisted Reproduction and Genetics, Volume 21 (Number 7). pp. 257-262. ISSN 1058-0468Full text not available from this repository.
Official URL: http://dx.doi.org/10.1023/B:JARG.0000042011.67696....
Purpose: Chronological age, or biological age as indicated by elevated FSH levels, are related to ovarian reserve. This study addresses the likelihood of cancellation of IVF treatment due to a poor ovarian response utilising both basal serum FSH and woman's age.
Methods: A prospective cohort of 536 infertile but ovulating women were studied in their first cycle of IVF treatment. Standardised methods of pituitary desensitisation and ovarian stimulation prior to IVF treatment were employed. Treatment cycles cancelled due to a poor ovarian response to gonadotrophins were studied. A series of logistic regression models were used to explore the probabilities of cancellation in relation to age and FSH.
Results: Both age and basal serum FSH levels were independently associated with the risk of treatment cancellation. A low risk of treatment cancellation was observed in women under the age of 35 irrespective of serum FSH, however in older women the risk of treatment cancellation was most likely in women with a high FSH.
Conclusions: In combination both age and FSH may serve as a valuable indicator of poor ovarian response leading to treatment cancellation. However, among older women FSH has particular importance, while less so in younger women with regular menstrual cycles.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH426 Genetics
R Medicine > RG Gynecology and obstetrics
|Divisions:||Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Journal of Assisted Reproduction and Genetics|
|Official Date:||July 2005|
|Number of Pages:||6|
|Page Range:||pp. 257-262|
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