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Os2-Os4 switch controls DNA knotting and anticancer activity
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Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201602995
Abstract
Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.
Item Type: | Journal Article | ||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Antineoplastic agents, Organometallic compounds | ||||||||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||||||||
Publisher: | Wiley | ||||||||||
ISSN: | 1433-7851 | ||||||||||
Official Date: | 25 July 2016 | ||||||||||
Dates: |
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Volume: | 55 | ||||||||||
Number: | 31 | ||||||||||
Number of Pages: | 5 | ||||||||||
Page Range: | pp. 8909-8912 | ||||||||||
DOI: | 10.1002/anie.201602995 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 11 July 2016 | ||||||||||
Date of first compliant Open Access: | 11 July 2016 | ||||||||||
Funder: | European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Birmingham Science City, European Regional Development Fund (ERDF), Advantage West Midlands (AWM), Spain. Ministerio de Economía y Competitividad [Ministry of Economy and Competitiveness] (MINECO) | ||||||||||
Grant number: | 247450 (ERC), EP/F034210/1 (EPSRC), BB/F011199/1 (BBSRC), 321791 (ERC), CTQ2012-39315 (MINECO), RYC-2011-07787 (MINECO) | ||||||||||
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