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Salivary and hair glucocorticoids and sleep in very preterm children during school age
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Maurer, Natalie, Perkinson-Gloor, Nadine, Stalder, Tobias, Arx, Priska Hagmann-von, Brand, Serge, Holsboer-Trachsler, Edith, Wellmann, Sven, Grob, Alexander, Weber, Peter and Lemola, Sakari (2016) Salivary and hair glucocorticoids and sleep in very preterm children during school age. Psychoneuroendocrinology, 72 . pp. 166-174. doi:10.1016/j.psyneuen.2016.07.003 ISSN 0306-4530.
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WRAP_1571912-ps-110716-maurer_et_al._psychoneuroendocrinology_final_accepted_version.pdf - Accepted Version - Requires a PDF viewer. Download (692Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.psyneuen.2016.07.003
Abstract
Very preterm birth involves increased stress for the child, which may lead to programming of the hypothalamic-pituitary-adrenal (HPA) axis activity and poor sleep in later life. Moreover, there is evidence for a relationship between HPA axis activity and sleep. However, research with objective sleep measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7β12 years were recruited for the present study. To assess HPA axis activity, salivary cortisol was measured at awakening, 10, 20, and 30β min later. In addition, hair cortisol and cortisone concentrations were quantified using liquid chromatography tandem mass spectrometry to assess cumulative endocrine activity over the preceding months. One night of in-home polysomnographic sleep assessment was conducted to assess sleep duration, sleep continuity, and sleep architecture. Children born very preterm showed significantly lower levels of cortisol at awakening and lower overall post-awakening cortisol secretion, lower cortisone in hair, and earlier sleep onset than full-term children. Across the whole sample, overall post-awakening cortisol secretion was positively related to sleep onset time and negatively to sleep duration. The association between prematurity status and post-awakening cortisol secretion was partially mediated by earlier sleep onset time. In conclusion, this study provides evidence for a possible down-regulation of the HPA axis activity and slightly earlier sleep phase in very preterm children during school age.
Item Type: | Journal Article | ||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||||||
Library of Congress Subject Headings (LCSH): | Premature infants -- Sleep -- Research, Children -- Sleep | ||||||||||
Journal or Publication Title: | Psychoneuroendocrinology | ||||||||||
Publisher: | Pergamon | ||||||||||
ISSN: | 0306-4530 | ||||||||||
Official Date: | October 2016 | ||||||||||
Dates: |
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Volume: | 72 | ||||||||||
Page Range: | pp. 166-174 | ||||||||||
DOI: | 10.1016/j.psyneuen.2016.07.003 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 13 July 2016 | ||||||||||
Date of first compliant Open Access: | 6 July 2017 |
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