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Beyond the discovery void : new targets for antibacterial compounds
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Broughton, Claire E., Berg, Hugo van den, Wemyss, Alan M., Roper, David I. and Rodger, Alison (2016) Beyond the discovery void : new targets for antibacterial compounds. Science Progress, 99 (2). pp. 153-182. doi:10.3184/003685016X14616130512308 ISSN 0036-8504.
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Official URL: https://doi.org/10.3184/003685016X14616130512308
Abstract
Antibiotics save many lives, but their efficacy is under threat: overprescription, population growth, and global travel all contribute to the rapid origination and spread of resistant strains. Exacerbating this threat is the fact that no new major classes of antibiotics have been discovered in the last 30 years: this is the "discovery void." We discuss the traditional molecular targets of antibiotics as well as putative novel targets.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) | ||||
| Journal or Publication Title: | Science Progress | ||||
| Publisher: | Science Reviews 2000 Ltd. | ||||
| ISSN: | 0036-8504 | ||||
| Official Date: | 1 June 2016 | ||||
| Dates: |
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| Volume: | 99 | ||||
| Number: | 2 | ||||
| Page Range: | pp. 153-182 | ||||
| DOI: | 10.3184/003685016X14616130512308 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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