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‘Grafting to’ of RAFTed responsive polymers to glass substrates by thiol-ene and critical comparison to thiol-gold coupling
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Biggs, Caroline I., Walker, Marc and Gibson, Matthew I. (2016) ‘Grafting to’ of RAFTed responsive polymers to glass substrates by thiol-ene and critical comparison to thiol-gold coupling. Biomacromolecules, 17 (8). pp. 2626-2633. doi:10.1021/acs.biomac.6b00662 ISSN 1525-7797.
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Official URL: http://dx.doi.org/10.1021/acs.biomac.6b00662
Abstract
Surface grafted polymers have been widely applied to modulate biological interfaces and introduce additional functionality. Polymers derived from RAFT polymerization have a masked thiol at the -chain end providing an anchor point for conjugation, and in particular displays high affinity for gold surfaces (both flat and particulate). In this work, we report the direct grafting of RAFTed polymers by a ‘thiol-ene click’ (Michael addition) onto glass substrates rather than gold, which provides a more versatile surface for subsequent array-based applications, but retaining the simplicity. The immobilisation of two thermoresponsive polymers are studied here; poly[oligo(ethylene glycol) methyl ether methacrylate] and poly(N-isopropylacrylamide). Using a range of surface analysis techniques the grafting efficiency was compared to thiol-gold and was quantitatively compared to the gold alternative using quartz crystal microbalance. It is shown that this method gives easy access to grafted polymer surfaces, with pNIPAM resulting in significantly increased surface coverage compared to pOEGMA. The non-fouling, (protein resistance) character of these surfaces is also demonstrated.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QD Chemistry | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Graft copolymers | ||||||
Journal or Publication Title: | Biomacromolecules | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 1525-7797 | ||||||
Official Date: | 13 July 2016 | ||||||
Dates: |
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Volume: | 17 | ||||||
Number: | 8 | ||||||
Page Range: | pp. 2626-2633 | ||||||
DOI: | 10.1021/acs.biomac.6b00662 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 18 July 2016 | ||||||
Date of first compliant Open Access: | 22 February 2017 | ||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Research Council (ERC), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF) | ||||||
Grant number: | BB/F017200/1 (BBSRC), 638661 (ERC) |
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