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Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases
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Heidari, Moones, Gerami, Sam H., Bassett, Brianna, Graham, Ross M., Chua, Anita C. G., Aryal, Ritambhara, House, Michael J., Collingwood, Joanna F., Bettencourt, Conceição, Houlden, Henry, Ryten, Mina, Olynyk, John K., Trinder, Debbie, Johnstone, Daniel M. and Milward, Elizabeth A. (2016) Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases. Rare Diseases, 4 (1). e1198458. doi:10.1080/21675511.2016.1198458
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Official URL: http://dx.doi.org/10.1080/21675511.2016.1198458
Abstract
We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe−/−xTfr2mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family ‘neurodegeneration with brain iron accumulation’ (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||||
| Divisions: | Faculty of Science > Engineering | ||||||||||
| Library of Congress Subject Headings (LCSH): | Hemochromatosis, Myelin proteins, Nervous system -- Degeneration | ||||||||||
| Journal or Publication Title: | Rare Diseases | ||||||||||
| Publisher: | Routledge | ||||||||||
| ISSN: | 2167-5511 | ||||||||||
| Official Date: | 2016 | ||||||||||
| Dates: |
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| Volume: | 4 | ||||||||||
| Number: | 1 | ||||||||||
| Article Number: | e1198458 | ||||||||||
| DOI: | 10.1080/21675511.2016.1198458 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | National Health and Medical Research Council (Australia) (NHMRC) , Fremantle Hospital Medical Research Foundation, Australian Society for Medical Research, Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England) | ||||||||||
| Grant number: | 572601 (NHMRC) , 1042370 (NHMRC) , 1020437 (NHMRC) , 1078747 (NHMRC), EP/D066654/1 (EPSRC), MR/J004758/1 (MRC), WT104033/Z/14/Z (WT) | ||||||||||
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