UNSPECIFIED. (2004) Effect of Enalapril and Losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gone. AMERICAN JOURNAL OF CARDIOLOGY, 94 (5). pp. 564-569. ISSN 0002-9149

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Abstract

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may have anti-inflammatory actions, an effect that could explain some of their beneficial effects on cardiovascular events in clinical trials. Coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and provides a convenient model to examine the effects of such agents. Genetic polymorphisms may be important in influencing the expression of cytokines, such as interleukin-6 (IL-6) We randomized men awaiting CABG to treatment with enalapril, losartan, or control for 2 months before surgery. Systemic IL-6, IL-8, IL-10, and IL-1 receptor agonists were measured before and after surgery, and genotypes for the -174 G/C and -572 G/C IL-6 gene polymorphisms were determined. Total release of the IL-1 receptor agonist was decreased 29% by enalapril and 31% by losartan (adjusted p = 0.041). IL-6 was decreased 17% by enalapril and 20% by losartan. Subjects possessing the -174 GG genotype produced 20% more IL-6 (adjusted p = 0.029). In these high producers of IL-6, release of IL-6 was decreased 51% by enalapril (adjusted p = 0.001) and 32% by losartan (adjusted p = 0.068). Release of IL-10 was nonsignificantly decreased 26% by enalapril and 21% by losartan, whereas IL-8 was not detected. In conclusion, enalapril and losartan significantly decreased release of the IL-1 receptor agonist after CABG. Enalapril produced a highly significant decrease of 51% in the release of IL-6 in patients identified as high producers of IL-6 by the -174 G/C polymorphism, whereas losartan has a similar but less marked effect. The production of IL-6 in this setting is influenced by the -174 G/C polymorphism. (C) 2004 by Excerpta Medica, Inc.

Item Type:	Journal Article
Subjects:	Q Science > QM Human anatomy
Journal or Publication Title:	AMERICAN JOURNAL OF CARDIOLOGY
Publisher:	EXCERPTA MEDICA INC
ISSN:	0002-9149
Date:	1 September 2004
Volume:	94
Number:	5
Number of Pages:	6
Page Range:	pp. 564-569
Identification Number:	10.1016/j.amjcard.2004.05.017
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/8065

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