The Library
Effect of Enalapril and Losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gone
Tools
UNSPECIFIED (2004) Effect of Enalapril and Losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gone. AMERICAN JOURNAL OF CARDIOLOGY, 94 (5). pp. 564-569. doi:10.1016/j.amjcard.2004.05.017 ISSN 0002-9149.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.amjcard.2004.05.017
Abstract
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may have anti-inflammatory actions, an effect that could explain some of their beneficial effects on cardiovascular events in clinical trials. Coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response and provides a convenient model to examine the effects of such agents. Genetic polymorphisms may be important in influencing the expression of cytokines, such as interleukin-6 (IL-6) We randomized men awaiting CABG to treatment with enalapril, losartan, or control for 2 months before surgery. Systemic IL-6, IL-8, IL-10, and IL-1 receptor agonists were measured before and after surgery, and genotypes for the -174 G/C and -572 G/C IL-6 gene polymorphisms were determined. Total release of the IL-1 receptor agonist was decreased 29% by enalapril and 31% by losartan (adjusted p = 0.041). IL-6 was decreased 17% by enalapril and 20% by losartan. Subjects possessing the -174 GG genotype produced 20% more IL-6 (adjusted p = 0.029). In these high producers of IL-6, release of IL-6 was decreased 51% by enalapril (adjusted p = 0.001) and 32% by losartan (adjusted p = 0.068). Release of IL-10 was nonsignificantly decreased 26% by enalapril and 21% by losartan, whereas IL-8 was not detected. In conclusion, enalapril and losartan significantly decreased release of the IL-1 receptor agonist after CABG. Enalapril produced a highly significant decrease of 51% in the release of IL-6 in patients identified as high producers of IL-6 by the -174 G/C polymorphism, whereas losartan has a similar but less marked effect. The production of IL-6 in this setting is influenced by the -174 G/C polymorphism. (C) 2004 by Excerpta Medica, Inc.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QM Human anatomy | ||||
Journal or Publication Title: | AMERICAN JOURNAL OF CARDIOLOGY | ||||
Publisher: | EXCERPTA MEDICA INC | ||||
ISSN: | 0002-9149 | ||||
Official Date: | 1 September 2004 | ||||
Dates: |
|
||||
Volume: | 94 | ||||
Number: | 5 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 564-569 | ||||
DOI: | 10.1016/j.amjcard.2004.05.017 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |