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Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex
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Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions, 45 . pp. 13034-13037. doi:10.1039/C6DT01382A ISSN 1477-9226.
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Official URL: http://dx.doi.org/10.1039/C6DT01382A
Abstract
We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Antineoplastic agents | ||||||||||||||||||
| Journal or Publication Title: | Dalton Transactions | ||||||||||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||||||||||
| ISSN: | 1477-9226 | ||||||||||||||||||
| Official Date: | 18 May 2016 | ||||||||||||||||||
| Dates: |
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| Volume: | 45 | ||||||||||||||||||
| Number of Pages: | 4 | ||||||||||||||||||
| Page Range: | pp. 13034-13037 | ||||||||||||||||||
| DOI: | 10.1039/C6DT01382A | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Date of first compliant deposit: | 5 August 2016 | ||||||||||||||||||
| Date of first compliant Open Access: | 8 August 2016 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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