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Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

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Venkatesh, Venkatesh, Wedge, Christopher, Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Transactions, 45 . pp. 13034-13037. doi:10.1039/C6DT01382A ISSN 1477-9226.

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Official URL: http://dx.doi.org/10.1039/C6DT01382A

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Abstract

We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Antineoplastic agents
Journal or Publication Title: Dalton Transactions
Publisher: Royal Society of Chemistry
ISSN: 1477-9226
Official Date: 18 May 2016
Dates:
DateEvent
18 May 2016Available
6 May 2016Accepted
9 April 2016Submitted
Volume: 45
Number of Pages: 4
Page Range: pp. 13034-13037
DOI: 10.1039/C6DT01382A
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 5 August 2016
Date of first compliant Open Access: 8 August 2016
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
EP/J500045/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
UNSPECIFIEDH2020 European Research Councilhttp://dx.doi.org/10.13039/100010663
Isaac Newton International FellowshipBritish Academyhttp://dx.doi.org/10.13039/501100000286
Isaac Newton International FellowshipAcademy of Medical Scienceshttp://dx.doi.org/10.13039/501100000691
Isaac Newton International FellowshipRoyal Societyhttp://dx.doi.org/10.13039/501100000288
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