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Gut dysbiosis in cystic fibrosis
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Scanlan, Pauline D., Buckling, Angus, Kong, Weidong, Wild, Yvette, Lynch, Susan V. and Harrison, Freya (2012) Gut dysbiosis in cystic fibrosis. Journal of Cystic Fibrosis, 11 (5). pp. 454-455. doi:10.1016/j.jcf.2012.03.007 ISSN 1569-1993.
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Official URL: http://dx.doi.org/10.1016/j.jcf.2012.03.007
Abstract
In people with CF, intestinal exocrine malfunction, antibiotic usage [1] and swallowing of infected respiratory mucus [2] likely perturb the normal community of commensal bacteria in the gut. People with CF report various intestinal problems which may be alleviated by probiotic administration [3]. There is also evidence that probiotic bacteria can help people with CF fight respiratory infection [4,5]. However, CF-related gut dysbiosis has only recently been subjected to detailed investigation. Using DGGE and culture-based methods, Duytschaever and colleagues [6] showed that children with CF have a quantitatively and qualitatively different faecal microbiota from their healthy siblings.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Journal of Cystic Fibrosis | ||||
Publisher: | Elsevier Science BV | ||||
ISSN: | 1569-1993 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | 11 | ||||
Number: | 5 | ||||
Page Range: | pp. 454-455 | ||||
DOI: | 10.1016/j.jcf.2012.03.007 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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