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Serotype-specific cell-mediated immunity associated with clearance of homotypic Group B Streptococcus rectovaginal colonization in pregnant women
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Kwatra , Gaurav, Adrian, Peter V., Shiri, Tinevimbo, Izu, Alane, Cutland, Clare L., Buchmann, Eckhart J. and Madhi, Shabir A. (2016) Serotype-specific cell-mediated immunity associated with clearance of homotypic Group B Streptococcus rectovaginal colonization in pregnant women. The Journal of Infectious Diseases, 213 (12). pp. 1923-1926. doi:10.1093/infdis/jiw056 ISSN 0022-1899.
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Official URL: http://dx.doi.org/10.1093/infdis/jiw056
Abstract
We investigated the association between group B Streptococcus (GBS) serotype-specific capsular polysaccharide cellular immunity, measured with enzyme-linked immunospot (ELISPOT) interferon γ release assay at 20 weeks gestation in pregnant women, and its effect on rectovaginal serotype-specific GBS colonization up to 37 weeks gestation. Among women colonized by serotype III at enrollment, interferon γ ELISPOT positivity was more common in those in whom colonization was cleared (44.4%) than in those in whom colonization persisted (7.4%; P = .008), with a similar trend observed for serotype Ia. Presence of serotype-specific capsular polysaccharide cell-mediated immunity contributes to the clearance of GBS rectovaginal colonization.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology > QR180 Immunology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The Journal of Infectious Diseases | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 0022-1899 | ||||||||
Official Date: | January 2016 | ||||||||
Dates: |
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Volume: | 213 | ||||||||
Number: | 12 | ||||||||
Page Range: | pp. 1923-1926 | ||||||||
DOI: | 10.1093/infdis/jiw056 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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Serotype-specific cell-mediated immunity associated with clearance of homotypic Group B Streptococcus rectovaginal colonization in pregnant women. (deposited 05 Apr 2016 11:07)
- Serotype-specific cell-mediated immunity associated with clearance of homotypic Group B Streptococcus rectovaginal colonization in pregnant women. (deposited 09 Aug 2016 13:15) [Currently Displayed]
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