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Second-generation probes for biosynthetic intermediate capture : towards a comprehensive profiling of polyketide assembly

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Wilkening, Ina, Gazzola, Silvia, Riva, Elena, Parascandolo, James S., Song, Lijiang and Tosin, Manuela (2016) Second-generation probes for biosynthetic intermediate capture : towards a comprehensive profiling of polyketide assembly. Chemical Communications, 52 (68). 10392-10395 . doi:10.1039/C6CC04681A

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Official URL: http://dx.doi.org/10.1039/C6CC04681A

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Abstract

Malonyl carba(dethia) N-decanoyl cysteamine methyl esters and novel acetoxymethyl esters were utilised as second-generation probes for polyketide intermediate capture. The use of these tools in vivo led to the characterisation of an almost complete set of biosynthetic intermediates from a modular assembly line, providing a first kinetic overview of intermediate processing leading to complex natural product formation.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Polyketides
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 4 September 2016
Dates:
DateEvent
4 September 2016Published
2 August 2016Available
28 June 2016Accepted
8 June 2016Submitted
Volume: 52
Number: 68
Number of Pages: 4
Page Range: 10392-10395
DOI: 10.1039/C6CC04681A
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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