Wilkening, Ina, Gazzola, Silvia, Riva, Elena, Parascandolo, James S., Song, Lijiang and Tosin, Manuela (2016) Second-generation probes for biosynthetic intermediate capture : towards a comprehensive profiling of polyketide assembly. Chemical Communications, 52 (68). 10392-10395 . doi:10.1039/C6CC04681A

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Abstract

Malonyl carba(dethia) N-decanoyl cysteamine methyl esters and novel acetoxymethyl esters were utilised as second-generation probes for polyketide intermediate capture. The use of these tools in vivo led to the characterisation of an almost complete set of biosynthetic intermediates from a modular assembly line, providing a first kinetic overview of intermediate processing leading to complex natural product formation.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Polyketides
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Official Date:	4 September 2016
Dates:	Date Event 4 September 2016 Published 2 August 2016 Available 28 June 2016 Accepted 8 June 2016 Submitted
Date of first compliant deposit:	9 August 2016
Volume:	52
Number:	68
Number of Pages:	4
Page Range:	10392-10395
DOI:	10.1039/C6CC04681A
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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