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Second-generation probes for biosynthetic intermediate capture : towards a comprehensive profiling of polyketide assembly
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Wilkening, Ina, Gazzola, Silvia, Riva, Elena, Parascandolo, James S., Song, Lijiang and Tosin, Manuela (2016) Second-generation probes for biosynthetic intermediate capture : towards a comprehensive profiling of polyketide assembly. Chemical Communications, 52 (68). 10392-10395 . doi:10.1039/C6CC04681A ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C6CC04681A
Abstract
Malonyl carba(dethia) N-decanoyl cysteamine methyl esters and novel acetoxymethyl esters were utilised as second-generation probes for polyketide intermediate capture. The use of these tools in vivo led to the characterisation of an almost complete set of biosynthetic intermediates from a modular assembly line, providing a first kinetic overview of intermediate processing leading to complex natural product formation.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Polyketides | ||||||||||
Journal or Publication Title: | Chemical Communications | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1359-7345 | ||||||||||
Official Date: | 4 September 2016 | ||||||||||
Dates: |
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Volume: | 52 | ||||||||||
Number: | 68 | ||||||||||
Number of Pages: | 4 | ||||||||||
Page Range: | 10392-10395 | ||||||||||
DOI: | 10.1039/C6CC04681A | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 9 August 2016 | ||||||||||
Date of first compliant Open Access: | 9 August 2016 |
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