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Success after failure : the role of endometrial stem cells in recurrent miscarriage

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Lucas, Emma S., Dyer, Nigel P., Fishwick, Katherine, Ott, Sascha and Brosens, Jan J. (2016) Success after failure : the role of endometrial stem cells in recurrent miscarriage. Reproduction, 152 (5). R159-R166. doi:10.1530/REP-16-0306

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Official URL: http://dx.doi.org/10.1530/REP-16-0306

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Abstract

Endometrial stem-like cells, including mesenchymal stem cells (MSCs) and epithelial progenitor cells, are essential for cyclic regeneration of the endometrium following menstrual shedding. Emerging evidence indicates that endometrial MSCs (eMSCs) constitute a dynamic population of cells that enables the endometrium to adapt in response to a failed pregnancy. Recurrent miscarriage is associated with relative depletion of endometrial eMSCs, which not only curtails the intrinsic ability of the endometrium to adapt to reproductive failure but also compromises endometrial decidualization, an obligatory transformation process for embryo implantation. These novel findings should pave the way for more effective screening of women at risk of pregnancy failure prior to conception.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science > Centre for Systems Biology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Miscarriage -- Prevention, Endometrium, Human embryo, Menstruation
Journal or Publication Title: Reproduction
Publisher: Biocentifica
ISSN: 1470-1626
Official Date: November 2016
Dates:
DateEvent
November 2016Published
18 July 2016Available
18 July 2016Accepted
Volume: 152
Number: 5
Page Range: R159-R166
DOI: 10.1530/REP-16-0306
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: University Hospitals Coventry and Warwickshire NHS Trust, Warwick Medical School, Tommy's (Charity)

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