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Success after failure : the role of endometrial stem cells in recurrent miscarriage
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Lucas, Emma S., Dyer, Nigel P., Fishwick, Katherine, Ott, Sascha and Brosens, Jan J. (2016) Success after failure : the role of endometrial stem cells in recurrent miscarriage. Reproduction, 152 (5). R159-R166. doi:10.1530/REP-16-0306
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Official URL: http://dx.doi.org/10.1530/REP-16-0306
Abstract
Endometrial stem-like cells, including mesenchymal stem cells (MSCs) and epithelial progenitor cells, are essential for cyclic regeneration of the endometrium following menstrual shedding. Emerging evidence indicates that endometrial MSCs (eMSCs) constitute a dynamic population of cells that enables the endometrium to adapt in response to a failed pregnancy. Recurrent miscarriage is associated with relative depletion of endometrial eMSCs, which not only curtails the intrinsic ability of the endometrium to adapt to reproductive failure but also compromises endometrial decidualization, an obligatory transformation process for embryo implantation. These novel findings should pave the way for more effective screening of women at risk of pregnancy failure prior to conception.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science > Centre for Systems Biology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Miscarriage -- Prevention, Endometrium, Human embryo, Menstruation | ||||||||
| Journal or Publication Title: | Reproduction | ||||||||
| Publisher: | Biocentifica | ||||||||
| ISSN: | 1470-1626 | ||||||||
| Official Date: | November 2016 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 10 August 2016 | ||||||||
| Volume: | 152 | ||||||||
| Number: | 5 | ||||||||
| Page Range: | R159-R166 | ||||||||
| DOI: | 10.1530/REP-16-0306 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | University Hospitals Coventry and Warwickshire NHS Trust, Warwick Medical School, Tommy's (Charity) |
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