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In vitro study of an intra-aortic VAD : effect of reverse-rotating mode on ventricular recovery
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Wang, Yaxin, Hsu, Po-Lin , Love, Holley C., Timms, Daniel L. and McMahon, Richard A. (2015) In vitro study of an intra-aortic VAD : effect of reverse-rotating mode on ventricular recovery. In: 37th annual international conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2015, Milan, 25-29 Aug 2015. Published in: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015 pp. 274-277. ISBN 9781424492701. doi:10.1109/EMBC.2015.7318353 ISSN 1094-687X.
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Official URL: http://dx.doi.org/10.1109/EMBC.2015.7318353
Abstract
Cardiac recovery has been observed in end-stage
heart failure patients with mechanical circulatory support. An
intra-aortic ventricular assist device (IntraVAD) is a novel
rotary blood pump designed to operate in the ascending aorta
behind the aortic valve, working in series with the compromised
left ventricle (LV). Such a device requires optimal motion
control in order to enhance the myocardial perfusion and thus
promote cardiac recovery. Therefore, a reverse-rotating control
(RRc) mode has been proposed to increase the mean arterial
pressure (MAP) in diastole where the most coronary flow
occurs. The RRc mode consists of two motions - forward
rotating speed (FS) and reversely rotating speed (RS). The
capability of cardiac recovery of three control modes, including
‘continuous’, ‘on/off ’ and ‘RRc’ modes, was evaluated in vitro.
Stroke work (SW), ventricular volume, coronary perfusion
pressure (CPP), and arterial pulsatility index (API) were used to
evaluate LV unloading, myocardial perfusion and arterial
pulsatility. The results show that, all three modes increased the
LV stroke work (0.98W vs 1.00W vs 1.01W for continuous,
on/off and RRc, respectively; baseline 0.9W) and decreased both
end-diastolic volume (EDV) and end-systolic volume (ESV). The
‘RRc” mode improved CPP significantly (78.4mmHg compared
to 66.4 mmHg and 70.9mmHg for continuous and on/off modes;
baseline 71mmHg). The arterial pulsatility was higher in ‘RRc’
mode (0.84 compared to 0.43 and 0.59; baseline 0.48). In
summary, the IntraVAD operating in the RRc mode can
successfully unload the LV, enhance the myocardial perfusion,
and restore the arterial pulsatility; therefore, it could be a
promising therapeutic option to bridge heart failure patients to
recovery.
Item Type: | Conference Item (Paper) | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | ||||
Publisher: | IEEE | ||||
ISBN: | 9781424492701 | ||||
ISSN: | 1094-687X | ||||
Book Title: | 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | ||||
Editor: | Cerutti, Sergio and Patton, Jim | ||||
Official Date: | 2015 | ||||
Dates: |
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Volume: | 2015 | ||||
Page Range: | pp. 274-277 | ||||
DOI: | 10.1109/EMBC.2015.7318353 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Description: | Sergio Cerutti; Jim Patton; Engineering in Medicine and Biology Society |
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Conference Paper Type: | Paper | ||||
Title of Event: | 37th annual international conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2015 | ||||
Type of Event: | Conference | ||||
Location of Event: | Milan | ||||
Date(s) of Event: | 25-29 Aug 2015 | ||||
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