Isahak, Naatasha, Sanchez, Julie, Perrier, Sébastien, Stone, Martin J. and Payne, Richard J. (2016) Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding. Organic and Biomolecular Chemistry, 14 (24). pp. 5652-5658. doi:10.1039/c6ob00270f ISSN 1477-0520.

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Abstract

The movement of leukocytes to the site of inflammation in response to injury or infection is orchestrated by chemokines binding and signaling through cognate receptors. The interaction between sulfated tyrosine residues on the flexible N-terminal tail of the receptor with positively charged regions of the chemokine is one of the key recognition features that facilitates binding. In this manuscript we describe the synthesis of polymers and silica nanoparticles bearing polystyrene sulfonate brushes to mimic the sulfated tyrosine residues. We show that both the polymers and nanoparticles possess high binding affinity for the chemokine monocyte chemoattractant protein-1 (MCP-1) in monomeric and dimeric form. We also demonstrate key differences in the relative affinity for the chemokine for the free polymer versus the polymer-derived nanoparticle system.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Journal or Publication Title:	Organic and Biomolecular Chemistry
Publisher:	RSC
ISSN:	1477-0520
Official Date:	28 June 2016
Dates:	Date Event 28 June 2016 Published 23 March 2016 Available 22 March 2016 Accepted 1 February 2016 Submitted
Volume:	14
Number:	24
Page Range:	pp. 5652-5658
DOI:	10.1039/c6ob00270f
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
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