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α-aldehyde terminally functional methacrylic polymers from living radical polymerization : application in protein conjugation “pegylation”
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Tao, Lei, Mantovani, Giuseppe, Lecolley, Francois and Haddleton, David M. (2004) α-aldehyde terminally functional methacrylic polymers from living radical polymerization : application in protein conjugation “pegylation”. Journal of the American Chemical Society, 126 (41). pp. 13220-13221. doi:10.1021/ja0456454 ISSN 0002-7863.
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Official URL: http://dx.doi.org/10.1021/ja0456454
Abstract
Application of proteins and peptides as human therapeutics is expanding rapidly as drug discovery becomes more prevalent. Conjugation of polymers to proteins can circumvent many problems and pegylation of proteins is now emerging as acceptable practice. This paper describes the synthesis of α-aldehyde-terminated poly(methoxyPEG)methacrylates from Cu(I) mediated living radical polymerization (Mn = 11 000, 22 000 and 32 000; PDi < 1.15), and their efficient conjugation to lysozyme, as a model protein. This offers an attractive and flexible alternative to linear poly(ethylene glycol) opening up the possibility of using the full power of living radical polymerization.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
| Library of Congress Subject Headings (LCSH): | Peptide drugs, Polypeptides, Proteins, Polymers | ||||||
| Journal or Publication Title: | Journal of the American Chemical Society | ||||||
| Publisher: | American Chemical Society | ||||||
| ISSN: | 0002-7863 | ||||||
| Official Date: | 2004 | ||||||
| Dates: |
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| Volume: | 126 | ||||||
| Number: | 41 | ||||||
| Page Range: | pp. 13220-13221 | ||||||
| DOI: | 10.1021/ja0456454 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 22 August 2016 | ||||||
| Date of first compliant Open Access: | 23 August 2016 | ||||||
| Funder: | Seventh Framework Programme (European Commission) (FP7), University of Warwick | ||||||
| Grant number: | HPRN-CT-2000-00010 (FP7) |
Data sourced from Thomson Reuters' Web of Knowledge
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