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Rh-catalyzed arylation of fluorinated ketones with arylboronic acids
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Dobson, Luca S. and Pattison, Graham (2016) Rh-catalyzed arylation of fluorinated ketones with arylboronic acids. Chemical Communications, 52 (74). 11116-11119 . doi:10.1039/C6CC05775F ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C6CC05775F
Abstract
The Rh-catalyzed arylation of fluorinated ketones with boronic acids is reported. This efficient process allows access to fluorinated alcohols in high yields under mild conditions. Competition experiments suggest that difluoromethyl ketones are more reactive than trifluoromethyl ketones in this process, despite their decreased electronic activation, an effect we postulate to be steric in origin.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Ketonic acids | ||||||||||
Journal or Publication Title: | Chemical Communications | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1359-7345 | ||||||||||
Official Date: | 25 September 2016 | ||||||||||
Dates: |
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Volume: | 52 | ||||||||||
Number: | 74 | ||||||||||
Page Range: | 11116-11119 | ||||||||||
DOI: | 10.1039/C6CC05775F | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 22 August 2016 | ||||||||||
Date of first compliant Open Access: | 16 August 2017 | ||||||||||
Funder: | Royal Society (Great Britain) |
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