Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Ultrasensitive negative feedback control : a natural approach for the design of synthetic controllers

Tools
- Tools
+ Tools

Montefusco, Francesco, Akman, Ozgur E., Soyer, Orkun S. and Bates, Declan (2016) Ultrasensitive negative feedback control : a natural approach for the design of synthetic controllers. PLoS One, 11 (8). e0161605. doi:10.1371/journal.pone.0161605

[img] PDF
WRAP_journal.pone.0161605_.PDF - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1232Kb)
Official URL: http://dx.doi.org/10.1371/journal.pone.0161605

Request Changes to record.

Abstract

Many of the most important potential applications of Synthetic Biology will require the ability to design and implement high performance feedback control systems that can accurately regulate the dynamics of multiple molecular species within the cell. Here, we argue that the use of design strategies based on combining ultrasensitive response dynamics with negative feedback represents a natural approach to this problem that fully exploits the strongly nonlinear nature of cellular information processing. We propose that such feedback mechanisms can explain the adaptive responses observed in one of the most widely studied biomolecular feedback systems—the yeast osmoregulatory response network. Based on our analysis of such system, we identify strong links with a well-known branch of mathematical systems theory from the field of Control Engineering, known as Sliding Mode Control. These insights allow us to develop design guidelines that can inform the construction of feedback controllers for synthetic biological systems.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science > Engineering
Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Synthetic biology, Bioengineering, Feedback control systems, Sliding mode control
Journal or Publication Title: PLoS One
Publisher: Public Library of Science
ISSN: 1932-6203
Official Date: 18 August 2016
Dates:
DateEvent
18 August 2016Available
8 August 2016Accepted
20 May 2016Submitted
Date of first compliant deposit: 24 August 2016
Volume: 11
Number: 8
Article Number: e0161605
DOI: 10.1371/journal.pone.0161605
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Engineering and Physical Sciences Research Council (EPSRC)
Grant number: EP/I017445/1

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us