Corticotropin releasing factor (CRF) peptide family and their receptors: Divergent actions influencing human physiology
UNSPECIFIED (2004) Corticotropin releasing factor (CRF) peptide family and their receptors: Divergent actions influencing human physiology. CURRENT GENOMICS, 5 (6). pp. 473-481. ISSN 1389-2029Full text not available from this repository.
Corticotropin-releasing factor (CRF) and its related peptides play a central role in the co-ordination of autonomic. behavioural. cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two G-protein-coupled receptors encoded by separate genes, termed CRF-R1 and -R2. In this review we focus on the structure, phylogeny, and expression of CRF peptide family. We present up-to-date literature on divergent actions of the CRF peptide family, including stress and behaviour, cardiovascular physiology, energy balance and reproduction. We also present a brief overview of CRF receptors including pharmacological aspects and potential therapeutic interventions for CRF receptors.
|Item Type:||Journal Item|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
|Journal or Publication Title:||CURRENT GENOMICS|
|Publisher:||BENTHAM SCIENCE PUBL LTD|
|Official Date:||August 2004|
|Number of Pages:||9|
|Page Range:||pp. 473-481|
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