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Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
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Wibowo, Anjar, Becker, Claude, Marconi, Gianpiero, Durr, Julius, Price, Jonathan, Hagmann, Jorg, Papareddy, Ranjith, Putra, Hadi, Kageyama, Jorge, Becker, Jorg, Weigel, Detlef and Gutierrez-Marcos, José F. (2016) Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity. eLife, 5 . e13546. doi:10.7554/eLife.13546
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Official URL: http://dx.doi.org/10.7554/eLife.13546
Abstract
Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QK Botany | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Arabidopsis -- Genetic aspects, Arabidopsis -- Genome mapping, Arabidopsis -- Evolution | ||||||||
| Journal or Publication Title: | eLife | ||||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||||
| ISSN: | 2050-084X | ||||||||
| Official Date: | 31 May 2016 | ||||||||
| Dates: |
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| Volume: | 5 | ||||||||
| Article Number: | e13546 | ||||||||
| DOI: | 10.7554/eLife.13546 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Royal Society (Great Britain), Estonian Science Foundation (ESF), COST Action, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Deutsche Forschungsgemeinschaft (DFG), Max-Planck-Gesellschaft zur Förderung der Wissenschaften [Max Planck Society for the Advancement of Science], Seventh Framework Programme (European Commission) (FP7) | ||||||||
| Grant number: | FA0903 (COST), BB/F008082 (BBSRC), FB 1101 - Project C01 (DFG), AENEAS, EVOREPRO (FP7) |
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