Huckstepp, Robert T. R., Henderson, Lauren E., Cardoza, Kathryn P. and Feldman, Jack L. (2016) Interactions between respiratory oscillators in adult rats. eLife, 5 . e14203. doi:10.7554/eLife.14203 ISSN 2050-084X.

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Abstract

Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region (pFL) driving active expiration. To understand the interactions between these oscillators, we independently altered their excitability in spontaneously breathing vagotomized urethane-anesthetized adult rats. Hyperpolarizing preBötC neurons decreased inspiratory activity and initiated active expiration, ultimately progressing to apnea, i.e., cessation of both inspiration and active expiration. Depolarizing pFL neurons produced active expiration at rest, but not when inspiratory activity was suppressed by hyperpolarizing preBötC neurons. We conclude that in anesthetized adult rats active expiration is driven by the pFL but requires an additional form of network excitation, i.e., ongoing rhythmic preBötC activity sufficient to drive inspiratory motor output or increased chemosensory drive. The organization of this coupled oscillator system, which is essential for life, may have implications for other neural networks that contain multiple rhythm/pattern generators.

Item Type:	Journal Article
Subjects:	Q Science > QL Zoology Q Science > QP Physiology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Respiration -- Rats -- Experimnets, Neurology -- Rats -- Research, Mammals -- Behavior
Journal or Publication Title:	eLife
Publisher:	eLife Sciences Publications Ltd.
ISSN:	2050-084X
Official Date:	14 June 2016
Dates:	Date Event 27 April 2016 Accepted 14 June 2016 Published 5 January 2016 Submitted
Volume:	5
Article Number:	e14203
DOI:	10.7554/eLife.14203
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	26 August 2016
Date of first compliant Open Access:	26 August 2016
Funder:	National Institutes of Health (U.S.) (NIH)
Grant number:	NIH HL 70029
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