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Interactions between respiratory oscillators in adult rats
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Huckstepp, Robert T. R., Henderson, Lauren E., Cardoza, Kathryn P. and Feldman, Jack L. (2016) Interactions between respiratory oscillators in adult rats. eLife, 5 . e14203. doi:10.7554/eLife.14203
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Official URL: http://dx.doi.org/10.7554/eLife.14203
Abstract
Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region (pFL) driving active expiration. To understand the interactions between these oscillators, we independently altered their excitability in spontaneously breathing vagotomized urethane-anesthetized adult rats. Hyperpolarizing preBötC neurons decreased inspiratory activity and initiated active expiration, ultimately progressing to apnea, i.e., cessation of both inspiration and active expiration. Depolarizing pFL neurons produced active expiration at rest, but not when inspiratory activity was suppressed by hyperpolarizing preBötC neurons. We conclude that in anesthetized adult rats active expiration is driven by the pFL but requires an additional form of network excitation, i.e., ongoing rhythmic preBötC activity sufficient to drive inspiratory motor output or increased chemosensory drive. The organization of this coupled oscillator system, which is essential for life, may have implications for other neural networks that contain multiple rhythm/pattern generators.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QL Zoology Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Respiration -- Rats -- Experimnets, Neurology -- Rats -- Research, Mammals -- Behavior | ||||||||
| Journal or Publication Title: | eLife | ||||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||||
| ISSN: | 2050-084X | ||||||||
| Official Date: | 14 June 2016 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 26 August 2016 | ||||||||
| Volume: | 5 | ||||||||
| Article Number: | e14203 | ||||||||
| DOI: | 10.7554/eLife.14203 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | National Institutes of Health (U.S.) (NIH) | ||||||||
| Grant number: | NIH HL 70029 | ||||||||
| Adapted As: |
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