The Library
High PEEP in ARDS : quantitative evaluation between improved oxygenation and decreased oxygen delivery
Tools
Tools
Tools
Chikhani, M., Das, Anup, Haque, M., Wang, Wenjie , Bates, Declan and Hardman, J. G. (2016) High PEEP in ARDS : quantitative evaluation between improved oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117 (5). pp. 650-658. doi:10.1093/bja/aew314 ISSN 0007-0912.
|
PDF
WRAP_aew314.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (772Kb) | Preview |
|
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP_High PEEP in ARDS_BJA_V1.2.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (504Kb) |
Official URL: https://doi.org/10.1093/bja/aew314
Abstract
Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial oxygenation, high PEEP strategies have demonstrated equivocal improvements in ARDS mortality. The effect of PEEP on tissue oxygen delivery is poorly understood and is difficult to quantify or investigate in the clinical environment.
Methods: We investigated the effects of PEEP on tissue oxygen delivery in ARDS using a novel, high-fidelity, computational model with highly integrated respiratory and cardiovascular systems. The model was configured to replicate published clinical trial data on the responses of 12 individual ARDS patients to changes in PEEP. These virtual patients were subjected to increasing PEEP levels during a lung-protective ventilation strategy (0 - 20 cmH2O). Measured variables included arterial oxygenation, cardiac output, peripheral oxygen delivery and alveolar strain.
Results: As PEEP increased, tissue oxygen delivery decreased in all subjects (mean reduction 25% at 20 cmH2O PEEP), despite an increase in arterial oxygen tension (mean increase 6.7 kPa, at 20 cmH2O PEEP). Changes in arterial oxygenation and tissue oxygen delivery differed between subjects, but showed a consistent pattern. Static and dynamic alveolar strain decreased in all patients as PEEP increased.
Conclusions: Incremental PEEP in ARDS appears to protect alveoli and improve arterial oxygenation, but also appears to significantly impair tissue oxygen delivery due to reduced cardiac output. We propose why this trade-off may explain the poor improvements in mortality associated with high PEEP ventilation strategies.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
| Library of Congress Subject Headings (LCSH): | Respiratory distress syndrome, Adult -- Treatment | ||||||
| Journal or Publication Title: | British Journal of Anaesthesia | ||||||
| Publisher: | Oxford University Press | ||||||
| ISSN: | 0007-0912 | ||||||
| Official Date: | 31 October 2016 | ||||||
| Dates: |
|
||||||
| Volume: | 117 | ||||||
| Number: | 5 | ||||||
| Page Range: | pp. 650-658 | ||||||
| DOI: | 10.1093/bja/aew314 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 31 August 2016 | ||||||
| Date of first compliant Open Access: | 28 February 2017 | ||||||
| Funder: | Medical Research Council (Great Britain) (MRC) | ||||||
| Grant number: | Grant number MR/K019783/1 | ||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
