Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution

Tools
- Tools
+ Tools

Penman, Bridget S., Moffett, Ashley, Chazara, Olympe, Gupta, Sunetra and Parham, Peter (2016) Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution. Immunogenetics, 68 (10). pp. 755-764. doi:10.1007/s00251-016-0935-9

[img] PDF
WRAP_art%3A10.1007%2Fs00251-016-0935-9.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1399Kb)
Official URL: http://dx.doi.org/10.1007/s00251-016-0935-9

Request Changes to record.

Abstract

Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure successful reproduction. Here we demonstrate that a combination of infectious disease selection and reproductive selection can drive the evolution of KIR B-like haplotypes from a KIR A-like founder haplotype. Continued selection to survive and to reproduce maintains a balance between KIR A and KIR B.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Killer cells
Journal or Publication Title: Immunogenetics
Publisher: Springer
ISSN: 0093-7711
Official Date: November 2016
Dates:
DateEvent
November 2016Published
12 August 2016Available
24 June 2016Accepted
Volume: 68
Number: 10
Page Range: pp. 755-764
DOI: 10.1007/s00251-016-0935-9
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Wellcome Trust (London, England), Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), European Research Council (ERC)
Grant number: WT096063MA (WT)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us