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Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution
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Penman, Bridget S., Moffett, Ashley, Chazara, Olympe, Gupta, Sunetra and Parham, Peter (2016) Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution. Immunogenetics, 68 (10). pp. 755-764. doi:10.1007/s00251-016-0935-9
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Official URL: http://dx.doi.org/10.1007/s00251-016-0935-9
Abstract
Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure successful reproduction. Here we demonstrate that a combination of infectious disease selection and reproductive selection can drive the evolution of KIR B-like haplotypes from a KIR A-like founder haplotype. Continued selection to survive and to reproduce maintains a balance between KIR A and KIR B.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Killer cells | ||||||||
| Journal or Publication Title: | Immunogenetics | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 0093-7711 | ||||||||
| Official Date: | November 2016 | ||||||||
| Dates: |
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| Volume: | 68 | ||||||||
| Number: | 10 | ||||||||
| Page Range: | pp. 755-764 | ||||||||
| DOI: | 10.1007/s00251-016-0935-9 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Wellcome Trust (London, England), Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), European Research Council (ERC) | ||||||||
| Grant number: | WT096063MA (WT) |
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